There are 5 ways to get from Mesa to Sioux Falls by plane, bus, train, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Phoenix
best- Fly from Phoenix (PHX) to Sioux Falls (FSD)plane PHX - FSD
5h 52m$84–404Bus, train
- Take the bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Stationbus
- Take the train from Flagstaff to Kansas Citytrain
- Take the bus from Kansas City to Sioux Fallsbus
40h 3m$452–944Bus
- Take the bus from Phoenix Bus Station to Oklahoma City Bus Stationbus
- Take the bus from Oklahoma City Bus Station to Kansas City Bus Stationbus
- Take the bus from Kansas City to Sioux Fallsbus
41h 39m$309–494Drive 1,366.6 mi
- Drive from Mesa to Sioux Fallscar 1,366.6 mi
25h 5m$250–361Fly from Phoenix-Mesa Gateway Airport
- Fly from Phoenix-Mesa Gateway Airport (AZA) to Sioux Falls (FSD)plane AZA - FSD
6h 7m$101–486
Phoenix (PHX) to Sioux Falls (FSD) flights
Comparing Your Travel Options
The cheapest way to get from Mesa to Sioux Falls is to fly which costs $80 - $410 and takes 5h 52m.
The fastest way to get from Mesa to Sioux Falls is to fly which takes 5h 52m and costs $80 - $410.
No, there is no direct bus from Mesa station to Sioux Falls. However, there are services departing from Phoenix Bus Station and arriving at The Bus Stop via Oklahoma City Bus Station, Kansas City and Maple/Career NE corner. The journey, including transfers, takes approximately 41h 39m.
The distance between Mesa and Sioux Falls is 1104 miles. The road distance is 1374.6 miles.
The best way to get from Mesa to Sioux Falls without a car is to bus and train which takes 40h 3m and costs $450 - $950.
It takes approximately 5h 52m to get from Mesa to Sioux Falls, including transfers.
Mesa to Sioux Falls bus services, operated by Greyhound USA, depart from Phoenix Bus Station.
The best way to get from Mesa to Sioux Falls is to fly which takes 5h 52m and costs $80 - $410. Alternatively, you can bus, which costs $300 - $500 and takes 41h 39m.
Mesa to Sioux Falls bus services, operated by Greyhound USA, arrive at Oklahoma City Bus Station.
Sioux Falls is 2h ahead of Mesa. It is currently 2:49 AM in Mesa and 4:49 AM in Sioux Falls.
What companies run services between Mesa, AZ, USA and Sioux Falls, SD, USA?
American Airlines, United Airlines, and Delta fly from Phoenix (PHX) to Sioux Falls (FSD) every 2 hours. Alternatively, you can take a vehicle from Mesa Dr/Main St to The Bus Stop via 44th St/Washington, Phoenix Sky Harbor Airport/44th Street Sky Train Station, 24th St Station, Phoenix Bus Station, Oklahoma City Bus Station, Kansas City Bus Station, Kansas City, Sioux Falls, and Maple/Career NE corner in around 41h 39m.
- Website
- aa.com
Flights from Phoenix to Sioux Falls
- Ave. Duration
- 2h 56m
- When
- Every day
- Estimated price
- $80–400
Flights from Phoenix to Sioux Falls via Dallas/Ft.Worth
- Ave. Duration
- 6h 29m
- When
- Every day
- Estimated price
- $110–490
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Flagstaff to Kansas City
- Ave. Duration
- 24h 27m
- Frequency
- Once daily
- Estimated price
- $320–750
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Phoenix Sky Harbor Airport/44th Street Sky Train Station to Flagstaff Train Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $22–35
- Schedules at
- Flixbus USA
Bus from Oklahoma City Bus Station to Kansas City Bus Station
- Ave. Duration
- 6h 20m
- Frequency
- 6 times a week
- Estimated price
- $50–85
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
Yes, the driving distance between Mesa to Sioux Falls is 1375 miles. It takes approximately 25h 5m to drive from Mesa to Sioux Falls.
There are 80+ hotels available in Sioux Falls.