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How to get fromMesa to St. Louisby plane, bus (Greyhound), bus, train, or car

Find Transport to St. Louis

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There are 5 ways to get from Mesa to St. Louis by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Phoenix (PHX) to Lambert–St. Louis International Airport (STL)plane plane PHX - STL
    5h 21m
    $165–755

  2. Bus (Greyhound)

    1. Take the bus from Phoenix Bus Station to St Louis Bus Stationbus bus Greyhound US1210
    32h 21m
    $232–442

  3. Bus, train via Kansas City

    1. Take the bus from Tempe to Flagstaff Train Stationbus bus
    2. Take the train from Flagstaff to Kansas Citytrain train
    3. Take the train from Kansas City to St. Louistrain train
    36h 19m
    $525–1,082

  4. Drive 1,438.4 mi

    1. Drive from Mesa to St. Louiscar car 1,438.4 mi
    23h 5m
    $263–380

  5. Bus, train (Amtrak)

    1. Take the bus from North Phoenix Metro Center Transit Station to Maricopa Amtrakbus bus Amtrak Thruway Connecting Service
    2. Take the train from Maricopa Amtrak to St. Louistrain train Texas Eagle
    2d 5h
    $674–1,433

Mesa to St. Louis by tram and bus (Greyhound)

Calendar14Weekly Services
Duration32h 21mAverage Duration
Ticket$232Cheapest Price
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Questions & Answers

Map of how to get from Mesa to St. Louis.ExpandLaunch map view
  • Distance: 1,285 mi
  • Duration: 5h 21m

What companies run services between Mesa, AZ, USA and St. Louis, MO, USA?

American Airlines and Southwest Airlines fly from Phoenix (PHX) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, Greyhound USA operates a bus from Phoenix Bus Station to St Louis Bus Station twice daily. Tickets cost $230–440 and the journey takes 30h 25m.

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