There are 6 ways to get from Mesquite to Santa Ana by bus, plane, train, car, shuttle, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, fly to John Wayne Airport Orange County
best- Take the bus from Mesquite, NV to Harry Reid Internationalbus
- Fly from Harry Reid International Airport (LAS) to John Wayne Airport Orange County (SNA)plane LAS - SNA
3h 46m$151–640Drive 345.5 mi
cheapest- Drive from Mesquite to Santa Anacar 345.5 mi
5h 38m$63–92Bus, train
- Take the bus from Mesquite, NV to Las Vegasbus
- Take the bus from Las Vegas to Valley Blvd - Bloomingtonbus
- Take the train from Riverside - Downtown to Santa Anatrain
7h 42m$122–178Bus, fly to Los Angeles International Airport, train
- Take the bus from Mesquite, NV to Harry Reid Internationalbus
- Fly from Harry Reid International Airport (LAS) to Los Angeles International Airport (LAX)plane LAS - LAX
- Take the train from Los Angeles to Santa Anatrain
6h 23m$140–991Shuttle, bus
- Take a shuttle bus from Mesquite, NV - Eureka Casino to Harry Reid International
- Take the bus from SB Las Vegas at Fashion Show Mall to San Bernardinobus
- Take the bus from San Bernardino to Harbor + Katellabus 200
11h 4m$84–99Bus
- Take the bus from Mesquite, NV to Harry Reid Internationalbus St George
- Take the bus from Las Vegas Strip to Anaheim Regional Transportation Intermodal Centerbus FlixBus 2037
11h 45m$78–146
Harry Reid International Airport (LAS) to John Wayne Airport Orange County (SNA) flights
Questions & Answers
The cheapest way to get from Mesquite to Santa Ana is to drive which costs $60 - $95 and takes 5h 38m.
The fastest way to get from Mesquite to Santa Ana is to bus and fly which takes 3h 46m and costs $150 - $650.
No, there is no direct bus from Mesquite to Santa Ana. However, there are services departing from Mesquite, NV and arriving at Main-1St via Harry Reid International, Las Vegas Strip and Artic - Dock 4. The journey, including transfers, takes approximately 11h 45m.
The distance between Mesquite and Santa Ana is 322 miles. The road distance is 347.5 miles.
The best way to get from Mesquite to Santa Ana without a car is to bus and train which takes 7h 42m and costs $120 - $180.
It takes approximately 3h 46m to get from Mesquite to Santa Ana, including transfers.
Mesquite to Santa Ana bus services, operated by Salt Lake Express, depart from Mesquite, NV station.
Mesquite to Santa Ana bus services, operated by Salt Lake Express, arrive at Harry Reid International station.
Yes, the driving distance between Mesquite to Santa Ana is 347 miles. It takes approximately 5h 38m to drive from Mesquite to Santa Ana.
There are 1413+ hotels available in Santa Ana.
What companies run services between Mesquite, NV, USA and Santa Ana, CA, USA?
You can take a bus from Mesquite, NV to Main-1St via Harry Reid International, WB Spring Mountain after Las Vegas, Las Vegas Strip, Anaheim Regional Transportation Intermodal Center, and Artic - Dock 4 in around 11h 45m.
- Website
- southwest.com
Flights from Harry Reid International Airport to John Wayne Airport Orange County
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- $50–340
Flights from Harry Reid International Airport to Los Angeles International Airport
- Ave. Duration
- 1h 16m
- When
- Every day
- Estimated price
- $30–210
- Website
- united.com
Flights from Harry Reid International Airport to Los Angeles International Airport
- Ave. Duration
- 1h 21m
- When
- Every day
- Estimated price
- $30–210
- Website
- jsx.com
Flights from Harry Reid International Airport to John Wayne Airport Orange County
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- $50–340
Flights from Harry Reid International Airport to Los Angeles International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $30–210
- Website
- delta.com
Flights from Harry Reid International Airport to John Wayne Airport Orange County
- Ave. Duration
- 1h 16m
- When
- Every day
- Estimated price
- $50–340
Flights from Harry Reid International Airport to Los Angeles International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- $30–210
- Website
- aa.com
Flights from Harry Reid International Airport to Los Angeles International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $30–210
- Website
- flyfrontier.com
Flights from Harry Reid International Airport to John Wayne Airport Orange County
- Ave. Duration
- 1h 16m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $85–230
Flights from Harry Reid International Airport to Los Angeles International Airport
- Ave. Duration
- 1h 18m
- When
- Every day
- Estimated price
- $85–190
- Website
- flybreeze.com
Flights from Harry Reid International Airport to John Wayne Airport Orange County
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- $110–600
- Phone
- (800) 371-LINK (5465)
- Website
- Metrolink Trains
Train from Riverside - Downtown to Santa Ana
- Ave. Duration
- 59 min
- Frequency
- Every 4 hours
- Estimated price
- $8–12
- Website
- Metrolink Trains
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Los Angeles to Santa Ana
- Ave. Duration
- 50 min
- Frequency
- Hourly
- Estimated price
- $11–23
- Website
- Amtrak
- Phone
- +1 208-656-8824
- [email protected]
- Website
- Salt Lake Express
Bus from Mesquite, NV to Harry Reid International
- Ave. Duration
- 1h 32m
- Frequency
- Every 4 hours
- Estimated price
- $22–55
- Website
- Salt Lake Express
Bus from Mesquite, NV to Harry Reid International
- Ave. Duration
- 1h 32m
- Frequency
- Every 4 hours
- Estimated price
- $22–55
- Website
- Salt Lake Express
Bus from Mesquite, NV to Harry Reid International
- Ave. Duration
- 1h 32m
- Frequency
- Every 4 hours
- Estimated price
- $22–55
- Website
- Salt Lake Express
- Phone
- +1 833 766 3553
- Website
- Tufesa
Bus from Mesquite, NV to Las Vegas
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $30–55
- Schedules at
- Tufesa
- Adult One way
- $30–55
Bus from Las Vegas to Valley Blvd - Bloomington
- Ave. Duration
- 3h 29m
- Frequency
- Once daily
- Estimated price
- $55–80
- Schedules at
- Tufesa
- Adult One way
- $55–80
- Phone
- +1 800-933-8320
- [email protected]
- Website
- St. George Shuttle
Shuttle from Mesquite, NV - Eureka Casino to Harry Reid International
- Ave. Duration
- 1h 50m
- Frequency
- Hourly
- Estimated price
- $30–45
- Website
- St. George Shuttle
- Phone
- +1 602-698-7800
- [email protected]
- Website
- Luxury Coach of America
Bus from SB Las Vegas at Fashion Show Mall to San Bernardino
- Ave. Duration
- 4h 10m
- Frequency
- 5 times a week
- Estimated price
- $45
- Schedules at
- Luxury Coach of America
- Phone
- +1 (951) 565-5002
- Website
- Riverside Transit Agency
Bus from San Bernardino to Harbor + Katella
- Ave. Duration
- 1h 53m
- Frequency
- Hourly
- Estimated price
- $1–5
- Website
- Riverside Transit Agency
- Children 46" tall and under
- $1–4
- Seniors 60+, Disabled, Medicare
- $1–4
- Adults and children over 46" tall
- $1–5
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Las Vegas Strip to Anaheim Regional Transportation Intermodal Center
- Ave. Duration
- 7h 25m
- Frequency
- Twice daily
- Estimated price
- $50–85
- Schedules at
- Flixbus USA
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