There are 6 ways to get from Mexicali to Panama City by plane, bus (Flixbus), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from General Rodolfo Sánchez Taboada International Airport
best- Fly from General Rodolfo Sánchez Taboada International Airport (MXL) to Tocumen International Airport (PTY)plane MXL - PTY
9h 10m$314–1,031Bus to San Diego International Airport, fly
cheapest- Take the bus from Mexicali to Tijuanabus
- Fly from San Diego International Airport (SAN) to Tocumen International Airport (PTY)plane SAN - PTY
12h 29m$191–641Bus
- Take the bus from Calexico Bus Station to Los Angeles Union Station Arrivalsbus
- Take the bus from Los Angeles to San Salvadorbus
- Take the bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San Josébus
- Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus
5d 13h$442–603Drive 5,738 km
- Drive from Mexicali to Panama Citycar 5,738 km
3d 1h$785–1,134Bus to Tijuana International Airport, fly
- Take the bus from Mexicali to Tijuana International Airportbus
- Fly from Tijuana International Airport (TIJ) to Tocumen International Airport (PTY)plane TIJ - PTY
13h 39m$237–820Fly from Imperial County Airport
- Fly from Imperial County Airport (IPL) to Tocumen International Airport (PTY)plane IPL - PTY
10h 28m$252–843
General Rodolfo Sánchez Taboada International Airport (MXL) to Tocumen International Airport (PTY) flights
Comparing Your Travel Options
The cheapest way to get from Mexicali to Panama City is to bus and fly which costs $190 - $650 and takes 12h 29m.
The fastest way to get from Mexicali to Panama City is to fly which takes 9h 10m and costs $310 - $1,100.
No, there is no direct bus from Mexicali to Panama City. However, there are services departing from Central de Autobuses de Mexicali and arriving at Terminal Tica Bus Panamá via Calexico Bus Station, Cesar E Chavez / Vignes, Los Angeles, Terminal Tica Bus San Salvador and Terminal Tica Bus San José. The journey, including transfers, takes approximately 5 days 13h.
The distance between Mexicali and Panama City is 4563 km. The road distance is 5738 km.
The best way to get from Mexicali to Panama City without a car is to bus which takes 5 days 13h and costs $440 - $650.
It takes approximately 9h 10m to get from Mexicali to Panama City, including transfers.
Mexicali to Panama City bus services, operated by Flixbus USA, depart from Calexico Bus Station.
The best way to get from Mexicali to Panama City is to fly which takes 9h 10m and costs $310 - $1,100. Alternatively, you can bus, which costs $440 - $650 and takes 5 days 13h.
Mexicali to Panama City bus services, operated by Flixbus USA, arrive at Los Angeles Union Station Arrivals.
Panama City is 3h ahead of Mexicali. It is currently 4:24 PM in Mexicali and 7:24 PM in Panama City.
What companies run services between Mexicali, Mexico and Panama City, Panama?
Volaris, Copa Airlines, and two other airlines fly from General Rodolfo Sánchez Taboada International Airport (MXL) to Tocumen International Airport (PTY) 5 times a day. Alternatively, you can take a bus from Central de Autobuses de Mexicali to Terminal Tica Bus Panamá via C. José Azueta y Blvr. López Mateos, Calexico Bus Station, Los Angeles Union Station Arrivals, Cesar E Chavez / Vignes, Los Angeles, San Salvador, Terminal Tica Bus San Salvador, and Terminal Tica Bus San José in around 5d 13h.
- Website
- copaair.com
Flights from General Rodolfo Sánchez Taboada International Airport to Tocumen International Airport via Mexico City
- Ave. Duration
- 10h 49m
- When
- Every day
- Estimated price
- $240–1,000
Flights from General Rodolfo Sánchez Taboada International Airport to Tocumen International Airport via Guadalajara
- Ave. Duration
- 8h 14m
- When
- Every day
- Estimated price
- $250–1,000
Flights from General Rodolfo Sánchez Taboada International Airport to Tocumen International Airport via Monterrey
- Ave. Duration
- 10h 24m
- When
- Monday and Sunday
- Estimated price
- $240–950
Flights from General Rodolfo Sánchez Taboada International Airport to Tocumen International Airport via Los Mochis, Mexico City
- Ave. Duration
- 14h 4m
- When
- Monday and Friday
- Estimated price
- $250–1,000
Flights from San Diego International Airport to Tocumen International Airport
- Ave. Duration
- 6h 6m
- When
- Monday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $130–550
Flights from Tijuana International Airport to Tocumen International Airport via Mexico City
- Ave. Duration
- 8h 52m
- When
- Every day
- Estimated price
- $180–750
Flights from Tijuana International Airport to Tocumen International Airport via Guadalajara
- Ave. Duration
- 8h 26m
- When
- Every day
- Estimated price
- $180–750
Flights from Tijuana International Airport to Tocumen International Airport via San Jose Cabo
- Ave. Duration
- 8h 44m
- When
- Monday, Thursday, and Saturday
- Estimated price
- $180–750
Flights from Tijuana International Airport to Tocumen International Airport via Cancun
- Ave. Duration
- 9h 11m
- When
- Every day
- Estimated price
- $290–1,500
Flights from Imperial County Airport to Tocumen International Airport via Los Angeles
- Ave. Duration
- 10h 23m
- When
- Every day
- Estimated price
- $210–800
- Website
- united.com
Flights from San Diego International Airport to Tocumen International Airport
- Ave. Duration
- 6h 6m
- When
- Monday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $130–550
Flights from San Diego International Airport to Tocumen International Airport via Houston
- Ave. Duration
- 8h 33m
- When
- Every day
- Estimated price
- $140–550
Flights from Imperial County Airport to Tocumen International Airport via Los Angeles
- Ave. Duration
- 9h 7m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $210–800
- Website
- aa.com
Flights from San Diego International Airport to Tocumen International Airport via Miami
- Ave. Duration
- 12h 33m
- When
- Every day
- Estimated price
- $150–600
- Website
- aeromexico.com
Flights from Tijuana International Airport to Tocumen International Airport via Mexico City
- Ave. Duration
- 10h 33m
- When
- Every day
- Estimated price
- $180–750
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Calexico Bus Station to Los Angeles Union Station Arrivals
- Ave. Duration
- 4h 39m
- Frequency
- 6 times a week
- Estimated price
- $35–55
- Schedules at
- Flixbus USA
- Phone
- +1 213 368 1172
- [email protected]
- Website
- busesusatours.com
Bus from Los Angeles to San Salvador
- Ave. Duration
- 3d 15h
- Frequency
- Once a week
- Estimated price
- $290–380
- Schedules at
- busesusatours.com
- Phone
- +52 962 625 2435
- [email protected]
- Website
- Tica Bus
Bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San José
- Ave. Duration
- 19h 30m
- Frequency
- 3 times a week
- Estimated price
- $60–85
- Website
- Tica Bus
Bus from Terminal Tica Bus San José to Terminal Tica Bus Panamá
- Ave. Duration
- 16h 10m
- Frequency
- Once daily
- Estimated price
- $55–80
- Website
- Tica Bus
- Phone
- +52 664 104 7400
- [email protected]
- Website
- abc.com.mx
Bus from Mexicali to Tijuana
- Ave. Duration
- 2h 5m
- Frequency
- Every 3 hours
- Estimated price
- $19–35
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
Bus from Mexicali to Tijuana International Airport
- Ave. Duration
- 2h 30m
- Frequency
- Twice daily
- Estimated price
- $18–35
- Schedules at
- abc.com.mx
- Book at
- abc.com.mx
Want to know more about travelling around Panama
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Booking & Getting There
Yes, the driving distance between Mexicali to Panama City is 5738 km. It takes approximately 3 days 1h to drive from Mexicali to Panama City.
There are 887+ hotels available in Panama City.





