There are 3 ways to get from Mexicali to Panama City by plane, bus (Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from General Rodolfo Sánchez Taboada International Airport (MXL) to Tocumen International Airport (PTY)plane MXL - PTY
9h 4m$274–881Bus
- Take the bus from Calexico Bus Station to Los Angeles Union Station Arrivalsbus
- Take the bus from Los Angeles to San Salvadorbus
- Take the bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San Josébus
- Take the bus from Terminal Tica Bus San José to Terminal Tica Bus Panamábus
5d 13h$437–603Drive 5,738 km
- Drive from Mexicali to Panama Citycar 5,738 km
3d 1h$785–1,134
General Rodolfo Sánchez Taboada International Airport (MXL) to Tocumen International Airport (PTY) flights
Comparing Your Travel Options
The cheapest way to get from Mexicali to Panama City is to fly which costs $270 - $900 and takes 9h 4m.
The fastest way to get from Mexicali to Panama City is to fly which takes 9h 4m and costs $270 - $900.
No, there is no direct bus from Mexicali to Panama City. However, there are services departing from Central de Autobuses de Mexicali and arriving at Terminal Tica Bus Panamá via Calexico Bus Station, Cesar E Chavez / Vignes, Los Angeles, Terminal Tica Bus San Salvador and Terminal Tica Bus San José. The journey, including transfers, takes approximately 5 days 13h.
The distance between Mexicali and Panama City is 4563 km. The road distance is 5738 km.
The best way to get from Mexicali to Panama City without a car is to bus which takes 5 days 13h and costs $430 - $650.
It takes approximately 9h 4m to get from Mexicali to Panama City, including transfers.
Mexicali to Panama City bus services, operated by Flixbus USA, depart from Calexico Bus Station.
The best way to get from Mexicali to Panama City is to fly which takes 9h 4m and costs $270 - $900. Alternatively, you can bus, which costs $430 - $650 and takes 5 days 13h.
Mexicali to Panama City bus services, operated by Flixbus USA, arrive at Los Angeles Union Station Arrivals.
Panama City is 2h ahead of Mexicali. It is currently 10:24 PM in Mexicali and 12:24 AM in Panama City.
What companies run services between Mexicali, Mexico and Panama City, Panama?
Volaris, Copa Airlines, and two other airlines fly from General Rodolfo Sánchez Taboada International Airport (MXL) to Tocumen International Airport (PTY) 3 times a day. Alternatively, you can take a bus from Central de Autobuses de Mexicali to Terminal Tica Bus Panamá via C. José Azueta y Blvr. López Mateos, Calexico Bus Station, Los Angeles Union Station Arrivals, Cesar E Chavez / Vignes, Los Angeles, San Salvador, Terminal Tica Bus San Salvador, and Terminal Tica Bus San José in around 5d 13h.
- Website
- copaair.com
Flights from General Rodolfo Sánchez Taboada International Airport to Tocumen International Airport via Mexico City
- Ave. Duration
- 8h 51m
- When
- Every day
- Estimated price
- $200–800
Flights from General Rodolfo Sánchez Taboada International Airport to Tocumen International Airport via Guadalajara
- Ave. Duration
- 9h 12m
- When
- Every day
- Estimated price
- $200–800
Flights from General Rodolfo Sánchez Taboada International Airport to Tocumen International Airport via Monterrey
- Ave. Duration
- 10h 30m
- When
- Monday and Sunday
- Estimated price
- $200–800
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Calexico Bus Station to Los Angeles Union Station Arrivals
- Ave. Duration
- 4h 39m
- Frequency
- 6 times a week
- Estimated price
- $30–55
- Schedules at
- Flixbus USA
- Phone
- +1 213 368 1172
- [email protected]
- Website
- busesusatours.com
Bus from Los Angeles to San Salvador
- Ave. Duration
- 3d 15h
- Frequency
- Once a week
- Estimated price
- $290–380
- Schedules at
- busesusatours.com
- Phone
- +52 962 625 2435
- [email protected]
- Website
- Tica Bus
Bus from Terminal Tica Bus San Salvador to Terminal Tica Bus San José
- Ave. Duration
- 19h 30m
- Frequency
- 3 times a week
- Estimated price
- $60–85
- Website
- Tica Bus
Bus from Terminal Tica Bus San José to Terminal Tica Bus Panamá
- Ave. Duration
- 16h 10m
- Frequency
- Once daily
- Estimated price
- $55–80
- Website
- Tica Bus
Want to know more about travelling around Panama
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Booking & Getting There
Yes, the driving distance between Mexicali to Panama City is 5738 km. It takes approximately 3 days 1h to drive from Mexicali to Panama City.
There are 903+ hotels available in Panama City.

