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How to get fromMexico City to Santa Anaby plane, bus, train, or car

Find Transport to Santa Ana

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There are 10 ways to get from Mexico City to Santa Ana by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Benito Juárez International Airport to John Wayne Airport Orange County

    best
    1. Fly from Benito Juárez International Airport (MEX) to John Wayne Airport Orange County (SNA)plane plane MEX - SNA
    7h 59m
    $159–687

  2. Bus via Morelia

    cheapest
    1. Take the bus from Terminal Poniente - Observatorio to Moreliabus bus
    2. Take the bus from Morelia to Santa Anabus bus
    45h 30m
    $120–305

  3. Bus, train via San Antonio

    1. Take the bus from Terminal Central de Autobuses del Norte to San Antoniobus bus
    2. Take the train from San Antonio Station to Los Angelestrain train
    3. Take the train from Los Angeles to Santa Anatrain train
    2d 3h
    $911–1,441

  4. Drive  1,794.3 mi

    1. Drive from Mexico City to Santa Anacar car 1,794.3 mi
    33h 7m
    $328–473

  5. Fly Benito Juárez International Airport to Tijuana International Airport, bus

    1. Fly from Benito Juárez International Airport (MEX) to Tijuana International Airport (TIJ)plane plane MEX - TIJ
    2. Take the bus from Tijuana Aeropuerto, B.C. to Santa Anabus bus
    7h 50m
    $130–297

  6. Fly Felipe Ángeles International Airport to Tijuana International Airport, bus

    1. Fly from Felipe Ángeles International Airport (NLU) to Tijuana International Airport (TIJ)plane plane NLU - TIJ
    2. Take the bus from Tijuana Aeropuerto, B.C. to Santa Anabus bus
    8h 35m
    $128–296

  7. Fly Licenciado Adolfo López Mateos International Airport to Tijuana International Airport, bus

    1. Fly from Licenciado Adolfo López Mateos International Airport (TLC) to Tijuana International Airport (TIJ)plane plane TLC - TIJ
    2. Take the bus from Tijuana Aeropuerto, B.C. to Santa Anabus bus
    8h 49m
    $168–300

  8. Fly Benito Juárez International Airport to Los Angeles International Airport, train

    1. Fly from Benito Juárez International Airport (MEX) to Los Angeles International Airport (LAX)plane plane MEX - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    8h 33m
    $166–405

  9. Bus

    1. Take the bus from Terminal Central de Autobuses del Norte to Tijuanabus bus
    2. Take the bus from Tijuana Central, B.C. to Santa Anabus bus Lxus 3126 / ...
    47h 21m
    $205–469

  10. Bus, train

    1. Take the bus from Terminal Central de Autobuses del Norte to Los Angelesbus bus
    2. Take the train from Los Angeles to Santa Anatrain train Pacific Surfliner
    2d 10h
    $217–262

Mexico City to Santa Ana by bus

Calendar7Weekly Buses
Duration45h 30mAverage Duration
Ticket$120Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mexico City to Santa Ana.ExpandLaunch map view
  • Distance: 1,525.8 mi
  • Duration: 7h 59m

What companies run services between Mexico City, Mexico and Santa Ana, CA, USA?

United Airlines, American Airlines, and six other airlines fly from Benito Juárez International Airport (MEX) to John Wayne Airport Orange County (SNA) every 2 hours. Alternatively, you can take a bus from Terminal Poniente - Observatorio to Santa Ana via Morelia in around 45h 30m.

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