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How to get fromMiddlesboro to Charlestonby car, plane, bus, or train

Find Transport to Charleston

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There are 7 ways to get from Middlesboro to Charleston by car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly

    best
    1. Drive from Middlesboro to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Charleston International Airport (CHS)plane plane TYS - CHS
    6h 37m
    $90–491

  2. Drive to Tri-Cities Regional Tn/Va Airport, fly

    cheapest
    1. Drive from Middlesboro to Tri-Cities-Regional-Airport-TRIcar car
    2. Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Charleston International Airport (CHS)plane plane TRI - CHS
    6h 48m
    $64–327

  3. Drive, bus, train

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Savannahbus bus
    4. Take the train from Savannah Station to Charleston Amtrak Stationtrain train
    15h 14m

  4. Drive 392.9 mi

    1. Drive from Middlesboro to Charlestoncar car 392.9 mi
    7h 8m
    $72–104

  5. Drive, bus

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Savannah Bus Stationbus bus
    4. Take the bus from Savannah Bus Station to Charleston Bus Stationbus bus
    17h 10m
    $110–223

  6. Drive, bus via Savannah

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Savannahbus bus
    4. Take the bus from Savannah Bus Station to Charleston Bus Stationbus bus
    17h 20m

  7. Drive, bus #2

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    21h 10m
    $128–253

Mcghee Tyson Airport (TYS) to Charleston International Airport (CHS) flights

Calendar106Weekly Planes
Duration4h 29mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from Middlesboro to Charleston.ExpandLaunch map view
  • Distance: 389.6 mi
  • Duration: 6h 37m

What companies run services between Middlesboro, KY, USA and Charleston, SC, USA?

There is no direct connection from Middlesboro to Charleston. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Charleston International Airport (CHS), walk to Charleston International Airport, then take the line 11 bus to Transit Mall. Alternatively, you can take a vehicle from Middlesboro to Charleston via London, Atlanta, Savannah, Savannah Station, and Charleston Amtrak Station in around 15h 14m.

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