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How to get fromMiddlesboro to Charlestonby car, plane, or bus

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There are 4 ways to get from Middlesboro to Charleston by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly

    best
    1. Drive from Middlesboro to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Charleston International Airport (CHS)plane plane TYS - CHS
    6h 32m
    $79–430
  2. Drive  392.9 mi

    cheapest
    1. Drive from Middlesboro to Charlestoncar car 392.9 mi
    7h 8m
    $68–97
  3. Drive, bus (Greyhound)

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    21h 10m
    $153–232
  4. Drive to Tri-Cities Regional Tn/Va Airport, fly

    1. Drive from Middlesboro to Tri-Cities-Regional-Airport-TRIcar car
    2. Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Charleston International Airport (CHS)plane plane TRI - CHS
    6h 55m
    $78–425

Mcghee Tyson Airport (TYS) to Charleston International Airport (CHS) flights

Calendar94Weekly Planes
Duration4h 13mAverage Duration
Ticket$65Cheapest Price
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Comparing Your Travel Options

What companies run services between Middlesboro, KY, USA and Charleston, SC, USA?

There is no direct connection from Middlesboro to Charleston. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Charleston International Airport (CHS), walk to Charleston International Airport, then take the line 11 bus to Transit Mall. Alternatively, you can take a vehicle from Middlesboro to Transit Mall via London, Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 21h 10m.

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