There are 4 ways to get from Middlesboro to Charleston by car, plane, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Mcghee Tyson Airport, fly
best- Drive from Middlesboro to Mcghee Tyson Airport (TYS)car
- Fly from Mcghee Tyson Airport (TYS) to Charleston International Airport (CHS)plane TYS - CHS
6h 32m$79–430Drive 392.9 mi
cheapest- Drive from Middlesboro to Charlestoncar 392.9 mi
7h 8m$68–97Drive, bus (Greyhound)
- Drive from Middlesboro to Londoncar
- Take the bus from London to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Charleston Bus Stationbus
21h 10m$153–232Drive to Tri-Cities Regional Tn/Va Airport, fly
- Drive from Middlesboro to Tri-Cities-Regional-Airport-TRIcar
- Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Charleston International Airport (CHS)plane TRI - CHS
6h 55m$78–425
Mcghee Tyson Airport (TYS) to Charleston International Airport (CHS) flights
Comparing Your Travel Options
The cheapest way to get from Middlesboro to Charleston is to drive which costs $65 - $100 and takes 7h 8m.
The fastest way to get from Middlesboro to Charleston is to drive and fly which takes 6h 32m and costs $75 - $430.
The distance between Middlesboro and Charleston is 392 miles. The road distance is 395.2 miles.
It takes approximately 6h 32m to get from Middlesboro to Charleston, including transfers.
Yes, the driving distance between Middlesboro to Charleston is 395 miles. It takes approximately 7h 8m to drive from Middlesboro to Charleston.
There are 1902+ hotels available in Charleston.
What companies run services between Middlesboro, KY, USA and Charleston, SC, USA?
There is no direct connection from Middlesboro to Charleston. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Charleston International Airport (CHS), walk to Charleston International Airport, then take the line 11 bus to Transit Mall. Alternatively, you can take a vehicle from Middlesboro to Transit Mall via London, Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 21h 10m.
- Website
- aa.com
Flights from Mcghee Tyson Airport to Charleston International Airport via Charlotte
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- $65–410
Flights from Tri-Cities Regional Tn/Va Airport to Charleston International Airport via Charlotte
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- $60–400
Flights from Tri-Cities Regional Tn/Va Airport to Charleston International Airport via Chicago O'Hare
- Ave. Duration
- 5h 23m
- When
- Every day
- Estimated price
- $120–650
- Website
- delta.com
Flights from Mcghee Tyson Airport to Charleston International Airport via Atlanta
- Ave. Duration
- 3h 54m
- When
- Every day
- Estimated price
- $70–430
Flights from Tri-Cities Regional Tn/Va Airport to Charleston International Airport via Atlanta
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $75–440
- Website
- southwest.com
Flights from Mcghee Tyson Airport to Charleston International Airport via Nashville
- Ave. Duration
- 4h 42m
- When
- Monday, Thursday, Friday, Sunday, Tuesday, and Wednesday
- Estimated price
- $80–470
Flights from Mcghee Tyson Airport to Charleston International Airport via Baltimore
- Ave. Duration
- 4h 50m
- When
- Monday to Thursday
- Estimated price
- $100–550
- Website
- united.com
Flights from Mcghee Tyson Airport to Charleston International Airport via Washington Dulles
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $100–550
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from London to Atlanta Bus Station
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- $55–85
- Website
- Greyhound
Bus from Atlanta Bus Station to Charleston Bus Station
- Ave. Duration
- 11h 20m
- Frequency
- Once daily
- Estimated price
- $85–130
- Website
- Greyhound
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