Rome2Rio

How to get fromMiddlesboro to Jacksonvilleby car, plane, or bus

Find Transport to Jacksonville

See all options

There are 5 ways to get from Middlesboro to Jacksonville by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Mcghee Tyson Airport, fly to Jacksonville

    best
    1. Drive from Middlesboro to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Jacksonville (JAX)plane plane TYS - JAX
    4h 37m
    $94–502

  2. Drive to Tri-Cities Regional Tn/Va Airport, fly to Jacksonville

    cheapest
    1. Drive from Middlesboro to Tri-Cities-Regional-Airport-TRIcar car
    2. Fly from Tri-Cities Regional Tn/Va Airport (TRI) to Jacksonville (JAX)plane plane TRI - JAX
    6h 42m
    $78–378

  3. Drive, bus

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Jacksonvillebus bus
    14h 36m
    $114–224

  4. Drive 567.3 mi

    1. Drive from Middlesboro to Jacksonvillecar car 567.3 mi
    9h 54m
    $104–150

  5. Drive to Mcghee Tyson Airport, fly to Orlando Sanford, drive

    1. Drive from Middlesboro to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Orlando Sanford (SFB)plane plane TYS - SFB
    3. Drive from Orlando-Sanford-Airport-SFB to Jacksonvillecar car
    5h 38m
    $115–524

Mcghee Tyson Airport (TYS) to Jacksonville (JAX) flights

Calendar20Weekly Planes
Duration3h 1mAverage Duration
Ticket$79Cheapest Price
See schedules

Questions & Answers

Map of how to get from Middlesboro to Jacksonville.ExpandLaunch map view
  • Distance: 481.2 mi
  • Duration: 4h 37m

What companies run services between Middlesboro, KY, USA and Jacksonville, FL, USA?

There is no direct connection from Middlesboro to Jacksonville. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Jacksonville (JAX), walk to Jia, then take the line 1 bus to JRTC Bay J. Alternatively, you can take a vehicle from Middlesboro to Jacksonville via London and Atlanta Bus Station in around 14h 36m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound