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How to get fromMiddlesboro to Louisvilleby car, plane, or bus

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There are 4 ways to get from Middlesboro to Louisville by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, fly

    best
    1. Drive from Middlesboro to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF)plane plane TYS - SDF
    6h 1m
    $124–772

  2. Drive  189.9 mi

    cheapest
    1. Drive from Middlesboro to Louisvillecar car 189.9 mi
    4h 12m
    $35–51

  3. Drive, bus via Brentwood

    1. Drive from Middlesboro to Knoxvillecar car
    2. Take the bus from Knoxville to Nashvillebus bus Nyc
    3. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    10h 47m
    $94–148

  4. Drive, bus

    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Cincinnati Bus Stationbus bus
    3. Take the bus from Cincinnati to Indianapolisbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    11h 21m
    $73–154

Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF) flights

Calendar111Weekly Planes
Duration4h 22mAverage Duration
Ticket$112Cheapest Price
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Comparing Your Travel Options

Map of how to get from Middlesboro to Louisville.ExpandLaunch map view
  • Distance: 269.8 mi
  • Duration: 6h 1m

What companies run services between Middlesboro, KY, USA and Louisville, KY, USA?

There is no direct connection from Middlesboro to Louisville. However, you can drive to Mcghee Tyson Airport (TYS) airport, fly to Louisville International Airport (SDF), walk to Louisville International Airport, then take the line 02 bus to 2nd @ York. Alternatively, you can take a vehicle from Middlesboro to W Jefferson @ S 5th via Knoxville, Nashville, Charlotte Pike & Lellyett St Eb, Central 5Th Ave - Bay 1, Central 4Th Ave - Bay 19, Walmart Station Outbound, Tornado Bus Co - Nashville, La Tropicana - Louisville, KY, and Preston @ Vim in around 10h 47m.

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