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How to get fromMiddlesboro to Louisvilleby car, bus, or plane

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There are 3 ways to get from Middlesboro to Louisville by car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus

    best
    1. Drive from Middlesboro to Londoncar car
    2. Take the bus from London to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    7h 16m
    $45–109

  2. Drive 189.9 mi

    cheapest
    1. Drive from Middlesboro to Louisvillecar car 189.9 mi
    4h 12m
    $35–51

  3. Drive, fly

    1. Drive from Middlesboro to Mcghee Tyson Airport (TYS)car car
    2. Fly from Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF)plane plane TYS - SDF
    5h 41m
    $109–622

Mcghee Tyson Airport (TYS) to Louisville International Airport (SDF) flights

Calendar96Weekly Planes
Duration4h 21mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Middlesboro to Louisville.ExpandLaunch map view
  • Distance: 328.8 mi
  • Duration: 7h 16m

What companies run services between Middlesboro, KY, USA and Louisville, KY, USA?

There is no direct connection from Middlesboro to Louisville. However, you can drive to London, take the bus to Cincinnati Bus Station, walk to Greyhound Station Cincinnati, then take the bus to Louisville, KY Bus Station. Alternatively, you can drive from Middlesboro to Louisville in around 4h 12m.

Airlines
Bus operators

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