Rome2Rio

How to get fromMiddletown to Buffaloby bus, train, plane, bus (Flixbus), car, subway, or bus (Greyhound)

Find Transport to Buffalo

See all options

There are 10 ways to get from Middletown to Buffalo by bus, train, plane, bus (Flixbus), car, subway, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train to Philadelphia International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the bus from Odessa Park & Ride to Wilmington Tcbus bus
    2. Take the train from Wilmington to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Buffalo Niagara International Airport (BUF)plane plane PHL - BUF
    6h 25m
    $109–1,238

  2. Drive 370.4 mi

    cheapest
    1. Drive from Middletown to Buffalocar car 370.4 mi
    7h 47m
    $68–98

  3. Bus

    1. Take the bus from Smyrna, DE - 134 N Dupont Blvd to Midtown - 400 8th Avebus bus Dover to New York
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus 2686 / ...
    13h 29m
    $102–178

  4. Bus, train

    1. Take the bus from Main St @ N Catherine St Eb to Newark Transit Hubbus bus 046
    2. Take the train from Wilmington to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    14h 1m
    $170–946

  5. Bus, train to Baltimore-Washington International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Odessa Park & Ride to Wilmington Tcbus bus
    2. Take the train from Wilmington to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Buffalo Niagara International Airport (BUF)plane plane BWI - BUF
    6h 20m
    $104–1,185

  6. Bus, train to Philadelphia International Airport, fly to Rochester

    1. Take the bus from Odessa Park & Ride to Wilmington Tcbus bus
    2. Take the train from Wilmington to 30th Street Stationtrain train
    3. Fly from Philadelphia International Airport (PHL) to Rochester (ROC)plane plane PHL - ROC
    4. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 38m
    $141–1,302

  7. Bus, train to Ronald Reagan Washington National Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Odessa Park & Ride to Wilmington Tcbus bus
    2. Take the train from Wilmington to New Carrollton Amtrak Stationtrain train
    3. Fly from Ronald Reagan Washington National Airport (DCA) to Buffalo Niagara International Airport (BUF)plane plane DCA - BUF
    7h 44m
    $160–911

  8. Bus, train to Baltimore-Washington International Airport, fly to Rochester

    1. Take the bus from Odessa Park & Ride to Wilmington Tcbus bus
    2. Take the train from Wilmington to BWI Thurgood Marshalltrain train
    3. Fly from Baltimore-Washington International Airport (BWI) to Rochester (ROC)plane plane BWI - ROC
    4. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 40m
    $141–1,249

  9. Bus, train, subway to Washington Dulles International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Odessa Park & Ride to Wilmington Tcbus bus
    2. Take the train from Wilmington to New Carrollton Amtrak Stationtrain train
    3. Take the subway from New Carrollton, Orange Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway
    4. Fly from Washington Dulles International Airport (IAD) to Buffalo Niagara International Airport (BUF)plane plane IAD - BUF
    8h 36m
    $108–558

  10. Bus via Wilmington

    1. Take the bus from Main St @ N Catherine St Eb to Newark Transit Hubbus bus 046
    2. Take the bus from Wilmington Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from Port Authority Bus Terminal to Buffalobus bus
    15h 6m
    $84–306

Middletown to Buffalo by bus and train

Calendar21Weekly Services
Duration14h 1mAverage Duration
Ticket$170Cheapest Price
See schedules

Questions & Answers

Map of how to get from Middletown to Buffalo.ExpandLaunch map view
  • Distance: 353.9 mi
  • Duration: 6h 25m

What companies run services between Middletown, DE, USA and Buffalo, NY, USA?

You can take a bus from Fz-Green St @ Cox St to Buffalo via Rt 13 @ Mt Vernon St - Sb, Smyrna, DE - 134 N Dupont Blvd, Midtown - 400 8th Ave, and New York Midtown in around 13h 29m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound