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How to get fromMiddletown to Chicagoby plane, train (Amtrak), bus (Flixbus), car, taxi, train, or bus (Greyhound)

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There are 8 ways to get from Middletown to Chicago by plane, train (Amtrak), bus (Flixbus), car, taxi, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Harrisburg International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD)plane plane MDT - ORD
    4h 2m
    $57–317

  2. Train via Pittsburgh (Amtrak)

    1. Take the train from Harrisburg to Pittsburgh Amtrak Stationtrain train Pennsylvanian
    2. Take the train from Pittsburgh Amtrak Station to Chicago Union Stationtrain train Floridian
    17h 27m
    $228–486

  3. Bus (Flixbus)

    1. Take the bus from Harrisburg Bus Station to Chicago Bus Stationbus bus FlixBus N2640 / ...
    18h 16m
    $121–202

  4. Drive 664.3 mi

    1. Drive from Middletown to Chicagocar car 664.3 mi
    10h 55m
    $122–176

  5. Taxi to Lancaster, fly to Chicago O'Hare International Airport

    1. Take the taxi from Middletown to Lancaster-Airport-LNStaxi taxi
    2. Fly from Lancaster (LNS) to Chicago O'Hare International Airport (ORD)plane plane LNS - ORD
    3h 43m
    $140–413

  6. Train to Philadelphia International Airport, fly to Chicago Midway International Airport

    1. Take the train from Middletown to 30th Street Stationtrain train
    2. Fly from Philadelphia International Airport (PHL) to Chicago Midway International Airport (MDW)plane plane PHL - MDW
    5h 55m
    $184–439

  7. Bus via Baltimore (Greyhound)

    1. Take the bus from Harrisburg Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0430
    2. Take the bus from Baltimore Downtown Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    23h 11m
    $123–244

  8. Train (Amtrak)

    1. Take the train from Middletown to 30th Street Stationtrain train Keystone Service
    2. Take the train from 30th Street Station to Chicago Union Stationtrain train Cardinal
    29h 44m
    $349–761

Middletown to Chicago by train (Amtrak)

Calendar7Weekly Trains
Duration17h 27mAverage Duration
Ticket$228Cheapest Price
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Questions & Answers

Map of how to get from Middletown to Chicago.ExpandLaunch map view
  • Distance: 612.9 mi
  • Duration: 4h 2m

What companies run services between Middletown, Dauphin County, PA, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Harrisburg International Airport (MDT) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a train from Middletown to Chicago Union Station via Harrisburg and Pittsburgh Amtrak Station in around 17h 27m.

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