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How to get fromMidtown Manhattan to Buffaloby subway, plane, train (Amtrak), bus (Flixbus), car, bus, or train

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There are 8 ways to get from Midtown Manhattan to Buffalo by subway, plane, train (Amtrak), bus (Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to John F. Kennedy International Airport, fly to Buffalo Niagara International Airport

    best
    1. Take the subway from 5 Av/53 St to Sutphin Blvd-Archer Av-JFK Airportsubway subway
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    3h 58m
    $82–480

  2. Bus

    cheapest
    1. Take the bus from New York Midtown to Buffalobus bus FlixBus 2686 / ...
    8h 35m
    $60–280

  3. Train

    1. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    8h 35m
    $110–290

  4. Drive  358.6 mi

    1. Drive from Midtown Manhattan to Buffalocar car 358.6 mi
    7h 15m
    $62–89

  5. Bus to Newark Liberty International Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Port Authority Bus Terminal to Terminal Bbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    4h 4m
    $110–643

  6. Subway to Laguardia Airport, fly to Buffalo Niagara International Airport

    1. Take the subway from 5 Av/53 St to Jackson Hts-Roosevelt Avsubway subway
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    4h 31m
    $111–739

  7. Fly Laguardia Airport to Rochester, bus

    1. Fly from Laguardia Airport (LGA) to Rochester (ROC)plane plane LGA - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    5h 38m
    $155–904

  8. Train via 5 Av/53 St

    1. Take the train from New York Penn Station to Buffalotrain train VIA Rail
    9h 26m
    $113–293

Midtown Manhattan to Buffalo by train

Calendar28Weekly Trains
Duration8h 35mAverage Duration
Ticket$110Cheapest Price
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Comparing Your Travel Options

Map of how to get from Midtown Manhattan to Buffalo.ExpandLaunch map view
  • Distance: 325.7 mi
  • Duration: 3h 58m

What companies run services between Midtown Manhattan, NY, USA and Buffalo, NY, USA?

Amtrak operates a train from Ny Moynihan Train Hall At Penn Station to Buffalo 3 times a day. Tickets cost $240–380 and the journey takes 8h 35m. VIA Rail also services this route once daily. Alternatively, Flixbus USA operates a bus from New York Midtown to Buffalo hourly. Tickets cost $70–110 and the journey takes 8h 35m. Trailways also services this route 5 times a day.

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