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How to get fromMilan to Iserniaby train (Trenitalia), bus, car, plane, or train

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There are 12 ways to get from Milan to Isernia by train (Trenitalia), bus, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Milano Centrale to Roma Terminitrain train Fr / ...
    2. Take the train from Roma Termini to Iserniatrain train Re
    6h 12m
    €97–202

  2. Train to Milano Malpensa Airport, fly to Naples Airport, train

    cheapest
    1. Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1train train
    2. Fly from Milano Malpensa Airport (MXP) to Naples Airport (NAP)plane plane MXP - NAP
    3. Take the train from Caserta to Iserniatrain train
    6h 59m
    €33–177

  3. Bus

    1. Take the bus from Milano, San Donato M3 to Termoli Autostazionebus bus Turin
    2. Take the bus from Termoli Terminal Bus to Iserniabus bus Cb 014 / ...
    8h 55m
    €56–95

  4. Drive 725.6 km

    1. Drive from Milan to Iserniacar car 725.6 km
    6h 44m
    €115–166

  5. Fly Milan Linate Airport to Fiumicino International Airport, train

    1. Fly from Milan Linate Airport (LIN) to Fiumicino International Airport (FCO)plane plane LIN - FCO
    2. Take the train from Roma Termini to Iserniatrain train
    6h 6m
    €78–229

  6. Train via Milan Rogoredo

    1. Take the train from Milan Rogoredo to Roma Terminitrain train 9975 / ...
    2. Take the train from Roma Termini to Iserniatrain train Re
    6h 31m
    €95–174

  7. Bus via Florence

    1. Take the bus from Milano, San Donato M3 to Florence Villa Constanza Bus Stationbus bus N528 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Iserniabus bus 433
    14h 19m
    €63–117

  8. Fly Milan Linate Airport to Naples Airport, train

    1. Fly from Milan Linate Airport (LIN) to Naples Airport (NAP)plane plane LIN - NAP
    2. Take the train from Caserta to Iserniatrain train
    6h 17m
    €64–214

  9. Fly Milan Linate Airport to Foggia Gino Lisa Airport, bus

    1. Fly from Milan Linate Airport (LIN) to Foggia Gino Lisa Airport (FOG)plane plane LIN - FOG
    2. Take the bus from Foggia to Iserniabus bus
    6h 31m
    €93–303

  10. Bus to Il Caravaggio International Airport, fly to Naples Airport, train

    1. Take the bus from Piazza Luigi di Savoia to Milan Bergamo Orio al Serio Airportbus bus
    2. Fly from Il Caravaggio International Airport (BGY) to Naples Airport (NAP)plane plane BGY - NAP
    3. Take the train from Caserta to Iserniatrain train
    7h 1m
    €52–247

  11. Train to Milano Malpensa Airport, fly to Abruzzo Airport, bus

    1. Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1train train
    2. Fly from Milano Malpensa Airport (MXP) to Abruzzo Airport (PSR)plane plane MXP - PSR
    3. Take the bus from Pescara to Iserniabus bus
    8h 4m
    €41–205

  12. Train to Milano Malpensa Airport, fly to Salerno Costa D'Amalfi Airport, train

    1. Take the train from Milano Porta Garibaldi to Malpensa Aeroporto T1train train
    2. Fly from Milano Malpensa Airport (MXP) to Salerno Costa D'Amalfi Airport (QSR)plane plane MXP - QSR
    3. Take the train from Salerno to Casertatrain train
    4. Take the train from Caserta to Iserniatrain train
    8h 41m
    €52–223

Milan to Isernia by train

Calendar70Weekly Trains
Duration6h 12mAverage Duration
Ticket€97Cheapest Price
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Questions & Answers

Map of how to get from Milan to Isernia.ExpandLaunch map view
  • Distance: 747.2 km
  • Duration: 6h 12m

What companies run services between Milan, Italy and Isernia, Italy?

You can take a train from Milano Centrale to Isernia via Roma Termini in around 6h 12m. Alternatively, you can take a bus from Milano, San Donato M3 to Isernia via Termoli Terminal Bus in around 8h 55m.

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