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How to get fromMilwaukee Airport (MKE) to Mayo Clinicby plane, bus, rideshare, or car

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There are 6 ways to get from Milwaukee Airport (MKE) to Mayo Clinic by plane, bus, rideshare, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly General Mitchell International Airport to Rochester

    best
    1. Fly from General Mitchell International Airport (MKE) to Rochester (RST)plane plane MKE - RST
    4h 43m
    $71–477

  2. Drive 280.5 mi

    cheapest
    1. Drive from Milwaukee Airport (MKE) to Mayo Cliniccar car 280.5 mi
    4h 43m
    $52–74

  3. Bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Mitchell Airport to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 9m
    $77–368

  4. Bus

    1. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    7h 16m
    $72–114

  5. Airport Transfer

    1. Take the rideshare from Milwaukee-MKE to Mayo Clinicrideshare rideshare 280.5 mi
    4h 43m

  6. Fly General Mitchell International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from General Mitchell International Airport (MKE) to Minneapolis–Saint Paul International Airport (MSP)plane plane MKE - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    4h 12m
    $685–1,022

Milwaukee Airport (MKE) to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration7h 16mAverage Duration
Ticket$72Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee Airport (MKE) to Mayo Clinic.ExpandLaunch map view
  • Distance: 248.9 mi
  • Duration: 4h 43m

What companies run services between Milwaukee Airport (MKE), USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from General Mitchell International Airport (MKE) to Rochester (RST) every 4 hours. Alternatively, Jefferson Lines operates a bus from Milwaukee to Rochester once daily. Tickets cost $70–100 and the journey takes 5h 40m.

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