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How to get fromMilwaukee to Buffalo Depew Stationby plane, train (Amtrak), bus, train, or car

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There are 6 ways to get from Milwaukee to Buffalo Depew Station by plane, train (Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Buffalo Niagara International Airport (BUF)plane plane MKE - BUF
    4h 44m
    $153–826

  2. Drive 623.4 mi

    cheapest
    1. Drive from Milwaukee to Buffalo Depew Stationcar car 623.4 mi
    10h 46m
    $114–165

  3. Train (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    12h 52m
    $198–406

  4. Bus, train

    1. Take the bus from Milwaukee Intermodal Station to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Torontobus bus
    3. Take the train from Toronto Union Station to Buffalotrain train
    19h 56m
    $132–352

  5. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    4h 35m
    $199–425

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    4h 52m
    $144–508

Milwaukee to Buffalo Depew Station by train (Amtrak)

Calendar14Weekly Trains
Duration12h 52mAverage Duration
Ticket$198Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Buffalo Depew Station.ExpandLaunch map view
  • Distance: 473.8 mi
  • Duration: 4h 44m

What companies run services between Milwaukee, WI, USA and Buffalo Depew Station, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from General Mitchell International Airport (MKE) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a train from Milwaukee to Buffalo Depew Station via Chicago Union Station in around 12h 52m.

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