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How to get fromMilwaukee to Charlestonby plane, train (Amtrak), bus, train, or car

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There are 7 ways to get from Milwaukee to Charleston by plane, train (Amtrak), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly General Mitchell International Airport to Charleston International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Charleston International Airport (CHS)plane plane MKE - CHS
    7h 2m
    $124–664

  2. Train (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    31h 8m
    $458–935

  3. Bus, train

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Newark Penn Stationbus bus
    3. Take the train from Newark Penn Station to Charleston Amtrak Stationtrain train
    35h 49m
    $378–721

  4. Drive 961 mi

    1. Drive from Milwaukee to Charlestoncar car 961 mi
    17h 38m
    $176–254

  5. Bus to Chicago O'Hare International Airport, fly to Charleston International Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    6h 44m
    $125–463

  6. Train to Chicago Midway International Airport, fly to Charleston International Airport

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    7h
    $135–615

  7. Bus to Chicago O'Hare International Airport, fly to Hilton Head Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Hilton Head Airport (HHH)plane plane ORD - HHH
    3. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 28m
    $136–458

Milwaukee to Charleston by bus and train

Calendar14Weekly Services
Duration35h 49mAverage Duration
Ticket$378Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Charleston.ExpandLaunch map view
  • Distance: 837.8 mi
  • Duration: 7h 2m

What companies run services between Milwaukee, WI, USA and Charleston, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Charleston International Airport (CHS) hourly. Alternatively, you can take a train from Milwaukee to Charleston via Chicago Union Station, Petersburg Amtrak Station, and Charleston Amtrak Station in around 31h 8m.

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