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How to get fromMilwaukee to Great Smoky Mountainsby plane, car, bus, or train

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There are 10 ways to get from Milwaukee to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly General Mitchell International Airport to Mcghee Tyson Airport, drive

    best
    1. Fly from General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS)plane plane MKE - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 36m
    $172–918

  2. Bus to Chicago O'Hare International Airport, fly to Asheville Regional Airport, drive

    cheapest
    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    3. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    6h 47m
    $112–403

  3. Bus, drive

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Union Station to Toledobus bus
    3. Take the bus from Toledo Bus Stop to Winston Salem(Trans Center)bus bus
    4. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    26h 21m
    $208–370

  4. Train, bus, drive

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    5. Drive from Asheville, NC to Great Smoky Mountainscar car
    35h 34m
    $429–926

  5. Drive 671 mi

    1. Drive from Milwaukee to Great Smoky Mountainscar car 671 mi
    12h 39m
    $123–177

  6. Bus to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 27m
    $148–657

  7. Fly General Mitchell International Airport to Hartsfield-Jackson Atlanta International Airport, drive

    1. Fly from General Mitchell International Airport (MKE) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane MKE - ATL
    2. Drive from Atlanta-Airport-ATL to Great Smoky Mountainscar car
    7h 34m
    $167–757

  8. Fly General Mitchell International Airport to Nashville, drive

    1. Fly from General Mitchell International Airport (MKE) to Nashville (BNA)plane plane MKE - BNA
    2. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    7h 33m
    $542–1,067

  9. Bus to Chicago O'Hare International Airport, fly to Greenville–Spartanburg International Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    3. Drive from Greenville–Spartanburg International Airport (GSP) to Great Smoky Mountainscar car
    7h 58m
    $157–626

  10. Bus, drive via Columbus

    1. Take the bus from Milwaukee Intermodal Station to Columbusbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    27h 31m
    $171–309

General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS) flights

Calendar110Weekly Planes
Duration4h 57mAverage Duration
Ticket$161Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 602.3 mi
  • Duration: 6h 36m

What companies run services between Milwaukee, WI, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Milwaukee to Great Smoky Mountains. However, you can take the bus to Airport, walk to General Mitchell International Airport (MKE) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Milwaukee Intermodal Station to Great Smoky Mountains via Chicago Bus Station, Chicago Union Station, Toledo Bus Stop, Winston Salem(Trans Center), and Asheville, NC in around 26h 21m.

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