There are 6 ways to get from Milwaukee to Jefferson City by plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly General Mitchell International Airport to Columbia Regional Airport
best- Fly from General Mitchell International Airport (MKE) to Columbia Regional Airport (COU)plane MKE - COU
5h 37m$162–572Drive 465.5 mi
cheapest- Drive from Milwaukee to Jefferson Citycar 465.5 mi
8h 14m$85–123Train (Amtrak)
- Take the train from Milwaukee to Chicago Union Stationtrain Hiawatha Service / ...
- Take the train from Chicago Union Station to Jefferson City Stationtrain Lincoln Service Missouri River Runner
10h 15m$122–278Bus
- Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Jefferson Citybus
13h 38m$92–148Bus to Chicago O'Hare International Airport, fly to Columbia Regional Airport
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Columbia Regional Airport (COU)plane ORD - COU
4h 44m$168–431Fly General Mitchell International Airport to Lambert–St. Louis International Airport, shuttle
- Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane MKE - STL
- Take a shuttle bus from St Louis International Airport to Jefferson City, Missouri
5h 40m$617–1,002
Milwaukee to Jefferson City by train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from Milwaukee to Jefferson City is to drive which costs $85 - $130 and takes 8h 14m.
The fastest way to get from Milwaukee to Jefferson City is to bus and fly which takes 4h 44m and costs $160 - $440.
No, there is no direct bus from Milwaukee station to Jefferson City. However, there are services departing from Milwaukee Intermodal Station and arriving at Jefferson City via Chicago Bus Station and St Louis Bus Station. The journey, including transfers, takes approximately 13h 38m.
No, there is no direct train from Milwaukee to Jefferson City station. However, there are services departing from Milwaukee and arriving at Jefferson City Station via Chicago Union Station. The journey, including transfers, takes approximately 10h 15m.
The distance between Milwaukee and Jefferson City is 396 miles. The road distance is 468.2 miles.
The best way to get from Milwaukee to Jefferson City without a car is to train which takes 10h 15m and costs $120 - $280.
It takes approximately 5h 37m to get from Milwaukee to Jefferson City, including transfers.
Milwaukee to Jefferson City bus services, operated by Greyhound USA, depart from Milwaukee Intermodal Station.
Milwaukee to Jefferson City train services, operated by Amtrak, depart from Milwaukee station.
The best way to get from Milwaukee to Jefferson City is to fly which takes 5h 37m and costs $160 - $600. Alternatively, you can train, which costs $120 - $280 and takes 10h 15m, you could also bus, which costs $90 - $150 and takes 13h 38m.
What companies run services between Milwaukee, WI, USA and Jefferson City, MO, USA?
United Airlines and American Airlines fly from General Mitchell International Airport (MKE) to Columbia Regional Airport (COU) every 4 hours. Alternatively, you can take a train from Milwaukee to Jefferson City Station via Chicago Union Station in around 10h 15m.
- Website
- united.com
Flights from General Mitchell International Airport to Columbia Regional Airport via Chicago O'Hare International Airport
- Ave. Duration
- 4h 9m
- When
- Every day
- Estimated price
- $70–460
Flights from General Mitchell International Airport to Columbia Regional Airport via Denver
- Ave. Duration
- 5h 55m
- When
- Every day
- Estimated price
- $180–800
Flights from Chicago O'Hare International Airport to Columbia Regional Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $40–280
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 3h 29m
- When
- Every day
- Estimated price
- $90–600
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $21–50
- Website
- Amtrak
Train from Chicago Union Station to Jefferson City Station
- Ave. Duration
- 7h 46m
- Frequency
- Once daily
- Estimated price
- $100–230
- Website
- Amtrak
#mediaviewer/File:Super_Dome_car.jpg "Hiawatha dome car")
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- 4 times a day
- Estimated price
- $13–22
- Website
- Greyhound
Bus from St Louis Bus Station to Jefferson City
- Ave. Duration
- 4h 5m
- Frequency
- Once daily
- Estimated price
- $26–45
- Website
- Greyhound
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Booking & Getting There
Milwaukee to Jefferson City bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Milwaukee to Jefferson City train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Milwaukee to Jefferson City is 468 miles. It takes approximately 8h 14m to drive from Milwaukee to Jefferson City.
Book your Milwaukee to Jefferson City train tickets online with Omio.
Book your Milwaukee to Jefferson City bus tickets online with Omio.
There are 19+ hotels available in Jefferson City.