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How to get fromMilwaukee to Jeffersonvilleby bus (Greyhound, Flixbus, Amtrak), train, bus, car, plane, or bus (Amtrak)

Find Transport to Jeffersonville

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There are 10 ways to get from Milwaukee to Jeffersonville by bus (Greyhound, Flixbus, Amtrak), train, bus, car, plane, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    10h 49m
    $65–86

  2. Train, bus (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    11h 10m
    $170–290

  3. Drive  381.2 mi

    1. Drive from Milwaukee to Jeffersonvillecar car 381.2 mi
    6h 42m
    $70–101

  4. Fly General Mitchell International Airport to Louisville International Airport

    1. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    6h 43m
    $124–758

  5. Bus via Chicago O'Hare Airport (ORD)

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus Wisconsin Coach Lines
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    11h 40m
    $94–112

  6. Bus to Chicago O'Hare International Airport, fly to Covington, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Covington (CVG)plane plane ORD - CVG
    3. Drive from Covington (CVG) to Jeffersonvillecar car
    5h 46m
    $205–866

  7. Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Jeffersonvillecar car
    5h 44m
    $91–340

  8. Bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    6h 44m
    $110–507

  9. Train to Chicago Midway International Airport, fly to Covington, drive

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Covington (CVG)plane plane MDW - CVG
    3. Drive from Covington (CVG) to Jeffersonvillecar car
    6h 17m
    $216–462

  10. Train to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    7h 2m
    $146–733

Milwaukee to Jeffersonville by bus and foot

Calendar14Weekly Services
Duration10h 49mAverage Duration
Ticket$65Cheapest Price
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Comparing Your Travel Options

Map of how to get from Milwaukee to Jeffersonville.ExpandLaunch map view
  • Distance: 392.5 mi
  • Duration: 10h 49m

What companies run services between Milwaukee, WI, USA and Jeffersonville, IN, USA?

You can take a bus from Milwaukee Intermodal Station to Court @ Meigs via Chicago Bus Station, Chicago Union Station, Louisville, KY, and Liberty @ Roy Wilkins in around 10h 49m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF) hourly.

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