There are 6 ways to get from Milwaukee to Kirksville by train (Amtrak), car, bus, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Milwaukee to Chicago Union Stationtrain Hiawatha Service / ...
- Take the train from Chicago Union Station to La Plata Stationtrain Southwest Chief
7h 38m$242–382Drive 390.3 mi
cheapest- Drive from Milwaukee to Kirksvillecar 390.3 mi
7h 49m$69–100Bus to Chicago O'Hare International Airport, fly to Kirksville Regional Airport
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 1 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK)plane ORD - IRK
4h 37m$157–400Bus, train
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus Wisconsin Coach Lines
- Take the train from Chicago Union Station to La Plata Stationtrain Southwest Chief
9h 22m$238–359Bus to Chicago O'Hare International Airport, fly to Burlington Municipal Airport, drive
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 1 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Burlington Municipal Airport (BRL)plane ORD - BRL
- Drive from Burlington Municipal Airport (BRL) to Kirksvillecar
7h 6m$133–351Fly General Mitchell International Airport to Kirksville Regional Airport
- Fly from General Mitchell International Airport (MKE) to Kirksville Regional Airport (IRK)plane MKE - IRK
5h 59m$206–681
Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK) flights
Comparing Your Travel Options
The cheapest way to get from Milwaukee to Kirksville is to drive which costs $65 - $100 and takes 7h 49m.
The fastest way to get from Milwaukee to Kirksville is to bus and fly which takes 4h 37m and costs $150 - $400.
No, there is no direct train from Milwaukee to Kirksville station. However, there are services departing from Milwaukee and arriving at La Plata Station via Chicago Union Station. The journey, including transfers, takes approximately 7h 38m.
The distance between Milwaukee and Kirksville is 397 miles. The road distance is 392.6 miles.
The best way to get from Milwaukee to Kirksville without a car is to train which takes 7h 38m and costs $240 - $390.
It takes approximately 7h 38m to get from Milwaukee to Kirksville, including transfers.
Milwaukee to Kirksville train services, operated by Amtrak, depart from Milwaukee station.
The best way to get from Milwaukee to Kirksville is to train which takes 7h 38m and costs $240 - $390. Alternatively, you can fly, which costs $200 - $700 and takes 5h 59m.
Milwaukee to Kirksville train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Milwaukee to Kirksville is 393 miles. It takes approximately 7h 49m to drive from Milwaukee to Kirksville.
What companies run services between Milwaukee, WI, USA and Kirksville, MO, USA?
You can take a train from Milwaukee to Kirksville via Chicago Union Station and La Plata Station in around 7h 38m. Alternatively, United Airlines, Corporate Flight Management Inc, and Delta fly from General Mitchell International Airport (MKE) to Kirksville Regional Airport (IRK) twice daily.
- Website
- contouraviation.com
Flights from Chicago O'Hare International Airport to Kirksville Regional Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $95–330
Flights from Chicago O'Hare International Airport to Burlington Municipal Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- $75–280
Flights from General Mitchell International Airport to Kirksville Regional Airport via Chicago O'Hare International Airport
- Ave. Duration
- 4h 22m
- When
- Monday to Saturday
- Estimated price
- $180–650
Flights from General Mitchell International Airport to Kirksville Regional Airport via Detroit, Chicago O'Hare International Airport
- Ave. Duration
- 9h 25m
- When
- Every day
- Estimated price
- $330–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $45–75
- Website
- Amtrak
Train from Chicago Union Station to La Plata Station
- Ave. Duration
- 4h 52m
- Frequency
- Once daily
- Estimated price
- $160–260
- Website
- Amtrak
Train from Chicago Union Station to La Plata Station
- Ave. Duration
- 4h 52m
- Frequency
- Once daily
- Estimated price
- $160–260
- Website
- Amtrak
#mediaviewer/File:Super_Dome_car.jpg "Hiawatha dome car")
- Phone
- (866) 912 6224
- [email protected]
- Website
- coachusa.com
Bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 1 Departures
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- $38–42
- Website
- coachusa.com
Bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departures
- Ave. Duration
- 2h
- Frequency
- Hourly
- Estimated price
- $38–42
- Website
- coachusa.com
Bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 1 Departures
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- $38–42
- Website
- coachusa.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
Book your Milwaukee to Kirksville train tickets online with Omio.
There are eight+ hotels available in Kirksville.