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How to get fromMilwaukee to Kirksvilleby bus, plane, train (Amtrak), car, or train

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There are 6 ways to get from Milwaukee to Kirksville by bus, plane, train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Chicago O'Hare International Airport, fly to Kirksville Regional Airport

    best
    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK)plane plane ORD - IRK
    4h 32m
    $138–276

  2. Drive 390.3 mi

    cheapest
    1. Drive from Milwaukee to Kirksvillecar car 390.3 mi
    7h 48m
    $72–103

  3. Train (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    7h 38m
    $168–310

  4. Bus to Chicago O'Hare International Airport, fly to Burlington Municipal Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Burlington Municipal Airport (BRL)plane plane ORD - BRL
    3. Drive from Burlington Municipal Airport (BRL) to Kirksvillecar car
    6h 59m
    $114–206

  5. Fly General Mitchell International Airport to Kirksville Regional Airport

    1. Fly from General Mitchell International Airport (MKE) to Kirksville Regional Airport (IRK)plane plane MKE - IRK
    6h 18m
    $167–707

  6. Bus, train

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus Wisconsin Coach Lines
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    8h 58m
    $180–301

Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK) flights

Calendar7Weekly Planes
Duration1h 30mAverage Duration
Ticket$68Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Kirksville.ExpandLaunch map view
  • Distance: 364.1 mi
  • Duration: 4h 32m

What companies run services between Milwaukee, WI, USA and Kirksville, MO, USA?

You can take a train from Milwaukee to Kirksville via Chicago Union Station and La Plata Station in around 7h 38m. Alternatively, American Airlines, Corporate Flight Management Inc, and Delta fly from General Mitchell International Airport (MKE) to Kirksville Regional Airport (IRK) twice daily.

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