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How to get fromMilwaukee to Knoxvilleby plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus, Greyhound)

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There are 10 ways to get from Milwaukee to Knoxville by plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly General Mitchell International Airport to Mcghee Tyson Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS)plane plane MKE - TYS
    5h 32m
    $257–1,272

  2. Bus to Chicago O'Hare International Airport, fly to Chattanooga Metropolitan Airport, drive

    cheapest
    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Chattanooga Metropolitan Airport (CHA)plane plane ORD - CHA
    3. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 21m
    $106–369

  3. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    36h 14m
    $730–1,175

  4. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    36h 21m
    $347–506

  5. Drive  614.5 mi

    1. Drive from Milwaukee to Knoxvillecar car 614.5 mi
    10h 50m
    $113–162

  6. Bus to Chicago O'Hare International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    4h 51m
    $203–811

  7. Fly General Mitchell International Airport to Nashville, drive

    1. Fly from General Mitchell International Airport (MKE) to Nashville (BNA)plane plane MKE - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 49m
    $532–1,052

  8. Train to Chicago Midway International Airport, fly to Mcghee Tyson Airport

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    5h 11m
    $274–1,247

  9. Train, bus via Ossining

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 52m
    $695–1,052

  10. Bus via Detroit

    1. Take the bus from Milwaukee Intermodal Station to Detroit Bus Stationbus bus
    2. Take the bus from Detroit Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 17m
    $361–528

General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS) flights

Calendar115Weekly Planes
Duration5h 3mAverage Duration
Ticket$204Cheapest Price
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Comparing Your Travel Options

Map of how to get from Milwaukee to Knoxville.ExpandLaunch map view
  • Distance: 555.9 mi
  • Duration: 5h 32m

What companies run services between Milwaukee, WI, USA and Knoxville, TN, USA?

Southwest Airlines, Delta, and two other airlines fly from General Mitchell International Airport (MKE) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to Knoxville via Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 36h 21m.

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