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How to get fromMilwaukee to Knoxvilleby plane, taxi, train, bus, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Milwaukee to Knoxville by plane, taxi, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport, taxi

    best
    1. Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)plane plane MKE - DSM
    2. Take the taxi from Des-Moines-Airport-DSM to Knoxvilletaxi taxi
    5h 53m
    $202–852

  2. Drive 357 mi

    cheapest
    1. Drive from Milwaukee to Knoxvillecar car 357 mi
    6h 31m
    $66–95

  3. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Oskaloosabus bus
    10h 15m
    $154–281

  4. Bus to Chicago O'Hare International Airport, fly, taxi

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    3. Take the taxi from Des-Moines-Airport-DSM to Knoxvilletaxi taxi
    5h 6m
    $193–631

  5. Train to Chicago Midway International Airport, fly, taxi

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    3. Take the taxi from Des-Moines-Airport-DSM to Knoxvilletaxi taxi
    5h 32m
    $207–814

  6. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus
    3. Take the bus from Des Moines to Monroebus bus
    11h 8m
    $102–174

  7. Bus, train

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Take the train from La Grange Amtrak to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Monroebus bus
    11h 55m
    $148–244

General Mitchell International Airport (MKE) to Des Moines (DSM) flights

Calendar143Weekly Planes
Duration4h 57mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Knoxville.ExpandLaunch map view
  • Distance: 353.1 mi
  • Duration: 5h 53m

What companies run services between Milwaukee, WI, USA and Knoxville, IA, USA?

You can take a bus from Milwaukee Intermodal Station to Knoxville via Chicago Bus Station, Des Moines, and Monroe in around 11h 8m.

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