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How to get fromMilwaukee to Locust St / 4Th Stby plane, train, bus, car, bus (Greyhound, Flixbus), or bus (Greyhound)

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There are 8 ways to get from Milwaukee to Locust St / 4Th St by plane, train, bus, car, bus (Greyhound, Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)plane plane MKE - DSM
    5h 12m
    $135–769

  2. Drive 356.4 mi

    cheapest
    1. Drive from Milwaukee to Locust St / 4Th Stcar car 356.4 mi
    6h 24m
    $65–94

  3. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    9h 16m
    $94–180

  4. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    4h 25m
    $126–538

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    4h 51m
    $146–730

  6. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150 / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    9h 17m
    $80–152

  7. Bus via Chicago O'Hare Airport (ORD)

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus Wisconsin Coach Lines
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    10h 28m
    $106–171

  8. Train, bus via Galesburg

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    11h 7m
    $119–245

General Mitchell International Airport (MKE) to Des Moines (DSM) flights

Calendar137Weekly Planes
Duration4h 56mAverage Duration
Ticket$121Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Locust St / 4Th St.ExpandLaunch map view
  • Distance: 322 mi
  • Duration: 5h 12m

What companies run services between Milwaukee, WI, USA and Locust St / 4Th St, IA, USA?

Delta, Southwest Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to Locust St / 4Th St via Chicago Bus Station and Des Moines in around 9h 17m.

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