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How to get fromMilwaukee to Louisvilleby bus (Greyhound, Flixbus), train, bus, car, plane, or shuttle

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There are 8 ways to get from Milwaukee to Louisville by bus (Greyhound, Flixbus), train, bus, car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    8h 40m
    $52–104

  2. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    10h 13m
    $95–215

  3. Drive  382.5 mi

    1. Drive from Milwaukee to Louisvillecar car 382.5 mi
    6h 44m
    $70–101

  4. Fly General Mitchell International Airport to Louisville International Airport

    1. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    5h 31m
    $113–705

  5. Bus, shuttle

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Take a shuttle bus from O'Hare International Terminal 2 to West Lafayette, INshuttle bus
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    12h 26m
    $99–152

  6. Bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    5h 29m
    $104–484

  7. Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 40m
    $91–350

  8. Train to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    5h 43m
    $114–661

Milwaukee to Louisville by bus

Calendar40Weekly Buses
Duration8h 40mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Louisville.ExpandLaunch map view
  • Distance: 386.8 mi
  • Duration: 8h 40m

What companies run services between Milwaukee, WI, USA and Louisville, KY, USA?

You can take a bus from Milwaukee Intermodal Station to Louisville Bus Station via Chicago Bus Station in around 8h 40m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF) hourly.

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