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How to get fromMilwaukee to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), train, bus, car, or bus (Amtrak)

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There are 8 ways to get from Milwaukee to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), train, bus, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly General Mitchell International Airport to Louisville International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    5h 31m
    $103–705

  2. Bus

    cheapest
    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    9h 44m
    $63–84

  3. Train, bus (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    10h 48m
    $102–228

  4. Drive 382.4 mi

    1. Drive from Milwaukee to Louisvillecar car 382.4 mi
    6h 43m
    $70–101

  5. Bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    5h 31m
    $104–474

  6. Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 40m
    $96–360

  7. Train to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    5h 43m
    $111–614

  8. Bus via Chicago O'Hare Airport (ORD)

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus Wisconsin Coach Lines
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    10h 48m
    $90–106

Milwaukee to Louisville by bus and foot

Calendar14Weekly Services
Duration9h 44mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Louisville.ExpandLaunch map view
  • Distance: 361.5 mi
  • Duration: 5h 31m

What companies run services between Milwaukee, WI, USA and Louisville, KY, USA?

Southwest Airlines, Delta, and two other airlines fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to Louisville, KY via Chicago Bus Station and Chicago Union Station in around 9h 44m.

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