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How to get fromMilwaukee to Louisville, KYby bus (Greyhound, Flixbus), train, bus, car, plane, bus (Amtrak), or subway

Find Transport to Louisville, KY

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There are 8 ways to get from Milwaukee to Louisville, KY by bus (Greyhound, Flixbus), train, bus, car, plane, bus (Amtrak), or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    9h 30m
    $59–103

  2. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    10h 28m
    $167–272

  3. Drive  384.3 mi

    1. Drive from Milwaukee to Louisville, KYcar car 384.3 mi
    6h 44m
    $71–102

  4. Fly General Mitchell International Airport to Louisville International Airport

    1. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    6h 3m
    $123–805

  5. Bus via Chicago O'Hare Airport (ORD)

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus Wisconsin Coach Lines
    2. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    10h 47m
    $93–109

  6. Bus to Chicago O'Hare International Airport, fly to Blue Grass Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    3. Drive from Lexington-Airport-LEX to Louisville, KYcar car
    5h 35m
    $91–331

  7. Bus to Chicago O'Hare International Airport, fly to Louisville International Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    6h 4m
    $109–514

  8. Train, subway to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the subway from LaSalle/Van Buren to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    6h 22m
    $150–780

Milwaukee to Louisville, KY by bus

Calendar40Weekly Buses
Duration9h 30mAverage Duration
Ticket$59Cheapest Price
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Comparing Your Travel Options

Map of how to get from Milwaukee to Louisville, KY.ExpandLaunch map view
  • Distance: 386.7 mi
  • Duration: 9h 30m

What companies run services between Milwaukee, WI, USA and Louisville, KY, USA?

You can take a bus from Milwaukee Intermodal Station to Louisville Bus Station via Chicago Bus Station in around 9h 30m. Alternatively, Southwest Airlines, United Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF) hourly.

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