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How to get fromMilwaukee to Louisville, KYby bus (Greyhound, Flixbus), train, bus, car, plane, or shuttle

Find Transport to Louisville, KY

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There are 7 ways to get from Milwaukee to Louisville, KY by bus (Greyhound, Flixbus), train, bus, car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150 / ...
    2. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    8h 45m
    $59–116

  2. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus
    10h 13m
    $110–230

  3. Drive 384.3 mi

    1. Drive from Milwaukee to Louisville, KYcar car 384.3 mi
    6h 44m
    $71–102

  4. Fly from General Mitchell International Airport

    1. Fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF)plane plane MKE - SDF
    6h 6m
    $103–665

  5. Bus, shuttle

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Take a shuttle bus from O'Hare International Terminal 2 to West Lafayette, INshuttle bus
    3. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus
    12h 24m
    $99–152

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    6h 3m
    $104–454

  7. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    6h 15m
    $114–616

Milwaukee to Louisville, KY by bus

Calendar82Weekly Buses
Duration8h 45mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Louisville, KY.ExpandLaunch map view
  • Distance: 386.8 mi
  • Duration: 8h 45m

What companies run services between Milwaukee, WI, USA and Louisville, KY, USA?

You can take a bus from Milwaukee Intermodal Station to Louisville Bus Station via Chicago Bus Station in around 8h 45m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from General Mitchell International Airport (MKE) to Louisville International Airport (SDF) hourly.

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