There are 6 ways to get from Milwaukee to Mayo Clinic by bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Milwaukee to Rochesterbus Jefferson Lines 966
5h 48m$70–100Drive 274.9 mi
cheapest- Drive from Milwaukee to Mayo Cliniccar 274.9 mi
4h 34m$51–73Fly General Mitchell International Airport to Rochester
- Fly from General Mitchell International Airport (MKE) to Rochester (RST)plane MKE - RST
6h 18m$73–482Fly General Mitchell International Airport to Minneapolis–Saint Paul International Airport, bus
- Fly from General Mitchell International Airport (MKE) to Minneapolis–Saint Paul International Airport (MSP)plane MKE - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
5h 33m$654–1,054Bus to Chicago O'Hare International Airport, fly to Rochester
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane ORD - RST
5h 39m$79–351Bus to Chicago O'Hare International Airport, fly to Waterloo Municipal Airport, drive
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Waterloo Municipal Airport (ALO)plane ORD - ALO
- Drive from Waterloo Municipal Airport (ALO) to Mayo Cliniccar
6h 27m$93–341
Milwaukee to Mayo Clinic by bus and foot
Questions & Answers
The cheapest way to get from Milwaukee to Mayo Clinic is to drive which costs $50 - $75 and takes 4h 34m.
The fastest way to get from Milwaukee to Mayo Clinic is to drive which takes 4h 34m and costs $50 - $75.
Yes, there is a direct bus departing from Milwaukee and arriving at Rochester. Services depart once daily, and operate every day. The journey takes approximately 5h 40m.
The distance between Milwaukee and Mayo Clinic is 280 miles. The road distance is 276.5 miles.
The best way to get from Milwaukee to Mayo Clinic without a car is to bus which takes 5h 48m and costs $70 - $100.
The bus from Milwaukee to Rochester takes 5h 40m including transfers and departs once daily.
Milwaukee to Mayo Clinic bus services, operated by Jefferson Lines, depart from Milwaukee station.
The best way to get from Milwaukee to Mayo Clinic is to bus which takes 5h 48m and costs $70 - $100. Alternatively, you can fly, which costs $70 - $490 and takes 6h 18m.
Milwaukee to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Rochester station.
Yes, the driving distance between Milwaukee to Mayo Clinic is 277 miles. It takes approximately 4h 34m to drive from Milwaukee to Mayo Clinic.
What companies run services between Milwaukee, WI, USA and Mayo Clinic, MN, USA?
Jefferson Lines operates a bus from Milwaukee to Rochester once daily. Tickets cost $70–100 and the journey takes 5h 40m. Alternatively, Delta, American Airlines, and United Airlines fly from General Mitchell International Airport (MKE) to Rochester (RST) every 4 hours.
- Website
- delta.com
Flights from General Mitchell International Airport to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 4h 9m
- When
- Every day
- Estimated price
- $70–450
Flights from General Mitchell International Airport to Rochester via Detroit, Minneapolis–Saint Paul International Airport
- Ave. Duration
- 6h 14m
- When
- Every day
- Estimated price
- $110–600
Flights from General Mitchell International Airport to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- $80–550
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Milwaukee to Rochester
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- $70–100
- Book at
- Jefferson Lines
- Adult
- $70–100
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