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How to get fromMilwaukee to Mayo Clinicby bus, car, or plane

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There are 5 ways to get from Milwaukee to Mayo Clinic by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    5h 48m
    $70–100

  2. Drive 274.9 mi

    cheapest
    1. Drive from Milwaukee to Mayo Cliniccar car 274.9 mi
    4h 34m
    $51–73

  3. Fly General Mitchell International Airport to Rochester

    1. Fly from General Mitchell International Airport (MKE) to Rochester (RST)plane plane MKE - RST
    6h 19m
    $86–471

  4. Bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    5h 37m
    $89–352

  5. Fly General Mitchell International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from General Mitchell International Airport (MKE) to Minneapolis–Saint Paul International Airport (MSP)plane plane MKE - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 40m
    $654–1,072

General Mitchell International Airport (MKE) to Rochester (RST) flights

Calendar48Weekly Planes
Duration4h 15mAverage Duration
Ticket$71Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Mayo Clinic.ExpandLaunch map view
  • Distance: 280 mi
  • Duration: 5h 48m

What companies run services between Milwaukee, WI, USA and Mayo Clinic, MN, USA?

Jefferson Lines operates a bus from Milwaukee to Rochester 3 times a day. Tickets cost $70–100 and the journey takes 5h 40m. Alternatively, Delta, American Airlines, and United Airlines fly from General Mitchell International Airport (MKE) to Rochester (RST) every 4 hours.

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