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How to get fromMilwaukee to Mount Pleasantby plane, bus, car, train (Amtrak), or train

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There are 8 ways to get from Milwaukee to Mount Pleasant by plane, bus, car, train (Amtrak), or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly General Mitchell International Airport to Charleston International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Charleston International Airport (CHS)plane plane MKE - CHS
    8h 26m
    $126–666

  2. Bus, drive

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Myrtle Beach Bus Stationbus bus
    4. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    5. Take the bus from S. Pinckney St / Society Rd to East Cooper Medical Centerbus bus
    30h 50m
    $190–365

  3. Train (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    31h 12m
    $468–956

  4. Drive 964.1 mi

    1. Drive from Milwaukee to Mount Pleasantcar car 964.1 mi
    17h 43m
    $176–255

  5. Bus to Chicago O'Hare International Airport, fly to Charleston International Airport

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    8h 8m
    $127–465

  6. Bus to Chicago O'Hare International Airport, fly to Hilton Head Airport, drive

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Hilton Head Airport (HHH)plane plane ORD - HHH
    3. Drive from Hilton Head Airport (HHH) to Mount Pleasantcar car
    7h 35m
    $137–460

  7. Train to Chicago Midway International Airport, fly to Charleston International Airport

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    8h 24m
    $137–618

  8. Train, bus, drive

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Myrtle Beach Bus Stationbus bus
    4. Drive from Myrtle Beach Bus Station to S. Pinckney St / Society Rdcar car
    5. Take the bus from S. Pinckney St / Society Rd to Stuart Engals Blvd / Wando Crossing Centerbus bus
    41h 42m
    $465–979

General Mitchell International Airport (MKE) to Charleston International Airport (CHS) flights

Calendar110Weekly Planes
Duration4h 49mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Mount Pleasant.ExpandLaunch map view
  • Distance: 845.5 mi
  • Duration: 8h 26m

What companies run services between Milwaukee, WI, USA and Mount Pleasant, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Charleston International Airport (CHS) hourly. Alternatively, you can take a train from Milwaukee to Mount Pleasant via Chicago Union Station, Petersburg Amtrak Station, and Charleston Amtrak Station in around 31h 12m.

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