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How to get fromMilwaukee to Saint Charlesby plane, bus, taxi, train (Amtrak), bus (Greyhound, Flixbus), car, or train

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There are 6 ways to get from Milwaukee to Saint Charles by plane, bus, taxi, train (Amtrak), bus (Greyhound, Flixbus), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport, line 34 bus, taxi

    best
    1. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    2. Take the bus from North Hanley Transit Center to 4375 Rider Trail North Sbbus bus
    3. Take the taxi from 4375 Rider Trail North Sb to Saint Charlestaxi taxi
    3h 57m
    $502–876

  2. Drive  385.2 mi

    cheapest
    1. Drive from Milwaukee to Saint Charlescar car 385.2 mi
    6h 34m
    $71–102

  3. Train (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    8h 49m
    $217–336

  4. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    10h 37m
    $77–120

  5. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    5h 26m
    $328–765

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    5h 56m
    $139–601

General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL) flights

Calendar20Weekly Planes
Duration1h 55mAverage Duration
Ticket$88Cheapest Price
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Comparing Your Travel Options

Map of how to get from Milwaukee to Saint Charles.ExpandLaunch map view
  • Distance: 344.8 mi
  • Duration: 3h 57m

What companies run services between Milwaukee, WI, USA and Saint Charles, MO, USA?

You can take a train from Milwaukee to Saint Charles via Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 8h 49m. Alternatively, you can take a bus from Milwaukee Intermodal Station to Saint Charles via Chicago Bus Station, St Louis Bus Station, Civic Center Transit Center, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 10h 37m.

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