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How to get fromMilwaukee to Saint Charlesby train (Amtrak), bus, taxi, car, plane, or train

Find Transport to Saint Charles

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There are 7 ways to get from Milwaukee to Saint Charles by train (Amtrak), bus, taxi, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the train from Chicago Union Station to Osceola Amtraktrain train California Zephyr
    9h 14m
    $182–356

  2. Drive 384.9 mi

    cheapest
    1. Drive from Milwaukee to Saint Charlescar car 384.9 mi
    6h 58m
    $71–102

  3. Bus, taxi

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus
    3. Take the taxi from Des Moines to Saint Charlestaxi taxi
    9h 46m
    $138–210

  4. Fly from General Mitchell International Airport

    1. Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)plane plane MKE - DSM
    5h 34m
    $172–817

  5. Bus, train

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus Wisconsin Coach Lines
    2. Take the train from Chicago Union Station to Osceola Amtraktrain train California Zephyr
    10h 33m
    $195–346

  6. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    4h 47m
    $163–596

  7. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    5h 13m
    $177–779

General Mitchell International Airport (MKE) to Des Moines (DSM) flights

Calendar143Weekly Planes
Duration4h 57mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Saint Charles.ExpandLaunch map view
  • Distance: 463.4 mi
  • Duration: 9h 14m

What companies run services between Milwaukee, WI, USA and Saint Charles, IA, USA?

You can take a train from Milwaukee to Saint Charles via Chicago Union Station and Osceola Amtrak in around 9h 14m. Alternatively, Delta, Southwest Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Des Moines (DSM) hourly.

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