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How to get fromMilwaukee to Sikestonby bus, plane, car, train, or taxi

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There are 7 ways to get from Milwaukee to Sikeston by bus, plane, car, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Chicago O'Hare International Airport, fly to Barkley Regional Airport, drive

    best
    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    3. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    5h 31m
    $93–346

  2. Drive  482.5 mi

    cheapest
    1. Drive from Milwaukee to Sikestoncar car 482.5 mi
    8h 5m
    $88–128

  3. Bus

    1. Take the bus from Water & Chicago - Circle K to Flying J - Matthewsbus bus Milwaukee
    9h 19m
    $133–158

  4. Train, drive (Amtrak)

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Fulton Amtrak Stationtrain train
    3. Drive from Fulton Amtrak Station to Sikestoncar car
    11h 45m
    $135–309

  5. Fly General Mitchell International Airport to Lambert–St. Louis International Airport, bus, taxi

    1. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    7h 3m
    $591–1,005

  6. Bus to Chicago O'Hare International Airport, fly to Williamson County Regional Airport, bus

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane plane ORD - MWA
    3. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus bus
    7h
    $173–342

  7. Fly General Mitchell International Airport to Nashville, bus, drive

    1. Fly from General Mitchell International Airport (MKE) to Nashville (BNA)plane plane MKE - BNA
    2. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    3. Drive from Paducah Bus Station to Sikestoncar car
    8h 21m
    $533–1,051

Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH) flights

Calendar7Weekly Planes
Duration1h 30mAverage Duration
Ticket$45Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Sikeston.ExpandLaunch map view
  • Distance: 479.5 mi
  • Duration: 5h 31m

What companies run services between Milwaukee, WI, USA and Sikeston, MO, USA?

Tornado Bus Company operates a bus from Water & Chicago - Circle K to Flying J - Matthews once daily. Tickets cost $100–120 and the journey takes 9h 5m.

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