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How to get fromMilwaukee to Sioux Fallsby plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus)

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There are 8 ways to get from Milwaukee to Sioux Falls by plane, train, bus, bus (Greyhound, Flixbus), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Sioux Falls (FSD)plane plane MKE - FSD
    6h 13m
    $89–484

  2. Train, bus

    1. Take the train from Milwaukee to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from Burnsville to Sioux Fallsbus bus Jefferson 701
    14h 1m
    $188–331

  3. Bus

    1. Take the bus from Milwaukee Intermodal Station to Minneapolis Bus Stationbus bus Greyhound US0150 / ...
    2. Take the bus from Minneapolis to Sioux Fallsbus bus Jefferson 701 / ...
    14h 8m
    $121–204

  4. Drive 499.4 mi

    1. Drive from Milwaukee to Sioux Fallscar car 499.4 mi
    8h 5m
    $92–132

  5. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Sioux Falls (FSD)plane plane ORD - FSD
    5h 57m
    $95–373

  6. Bus to Dane County Regional Airport-Truax Field, fly

    1. Take the bus from Milwaukee, WI - Amtrak to Madison, WI-Lake St.bus bus
    2. Fly from Dane County Regional Airport-Truax Field (MSN) to Sioux Falls (FSD)plane plane MSN - FSD
    8h 20m
    $91–468

  7. Bus to Appleton International Airport, fly

    1. Take the bus from Milwaukee to Appletonbus bus
    2. Fly from Appleton International Airport (ATW) to Sioux Falls (FSD)plane plane ATW - FSD
    8h 34m
    $89–378

  8. Bus via Airport

    1. Take the bus from Milwaukee Mitchell Airport to Minneapolis Bus Stationbus bus FlixBus 2548
    2. Take the bus from Minneapolis to Sioux Fallsbus bus Jefferson 701 / ...
    17h 5m
    $124–199

General Mitchell International Airport (MKE) to Sioux Falls (FSD) flights

Calendar114Weekly Planes
Duration5h 10mAverage Duration
Ticket$86Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to Sioux Falls.ExpandLaunch map view
  • Distance: 459.4 mi
  • Duration: 6h 13m

What companies run services between Milwaukee, WI, USA and Sioux Falls, SD, USA?

Delta, United Airlines, and American Airlines fly from General Mitchell International Airport (MKE) to Sioux Falls (FSD) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to The Bus Stop via Minneapolis, Sioux Falls, and Maple/Career NE corner in around 14h 8m.

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