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How to get fromMilwaukee to West Des Moinesby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)

Find Transport to West Des Moines

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There are 9 ways to get from Milwaukee to West Des Moines by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)plane plane MKE - DSM
    5h 6m
    $90–475

  2. Drive  361.5 mi

    cheapest
    1. Drive from Milwaukee to West Des Moinescar car 361.5 mi
    6h 31m
    $62–90

  3. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S / ...
    11h 15m
    $96–146

  4. Train, bus via Saint Paul

    1. Take the train from Milwaukee to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from Saint Paul Union Depot to Des Moinesbus bus Greyhound US0156
    11h 37m
    $245–370

  5. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 1 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    4h 34m
    $96–324

  6. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    5h
    $132–529

  7. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    11h 15m
    $189–298

  8. Train, bus #2

    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S / ...
    11h 18m
    $129–193

  9. Bus via Airport

    1. Take the bus from Milwaukee Mitchell Airport to Chicago Bus Stationbus bus FlixBus 2548 / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S / ...
    13h 2m
    $97–144

General Mitchell International Airport (MKE) to Des Moines (DSM) flights

Calendar142Weekly Planes
Duration4h 59mAverage Duration
Ticket$71Cheapest Price
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Comparing Your Travel Options

Map of how to get from Milwaukee to West Des Moines.ExpandLaunch map view
  • Distance: 323.6 mi
  • Duration: 5h 6m

What companies run services between Milwaukee, WI, USA and West Des Moines, IA, USA?

Southwest Airlines, United Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to West Des Moines via Chicago Bus Station and Des Moines in around 11h 15m.

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