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How to get fromMilwaukee to West Des Moinesby plane, train, bus, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Milwaukee to West Des Moines by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)plane plane MKE - DSM
    5h 17m
    $139–783

  2. Drive 361.5 mi

    cheapest
    1. Drive from Milwaukee to West Des Moinescar car 361.5 mi
    6h 31m
    $66–96

  3. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the bus from Chicago to Des Moinesbus bus Btw 1205 / ...
    9h 58m

  4. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    4h 27m
    $130–542

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    4h 52m
    $150–734

  6. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus Greyhound US0150 / ...
    2. Take the bus from Chicago to Des Moinesbus bus Btw 1205 / ...
    10h

  7. Train, bus via Galesburg

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    11h 15m
    $131–258

  8. Bus via Rochester

    1. Take the bus from Milwaukee to Rochesterbus bus
    2. Take the bus from Rochester to Albert Leabus bus
    3. Take the bus from Albert Lea to Des Moinesbus bus
    12h 25m

General Mitchell International Airport (MKE) to Des Moines (DSM) flights

Calendar137Weekly Planes
Duration4h 56mAverage Duration
Ticket$121Cheapest Price
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Questions & Answers

Map of how to get from Milwaukee to West Des Moines.ExpandLaunch map view
  • Distance: 323.7 mi
  • Duration: 5h 17m

What companies run services between Milwaukee, WI, USA and West Des Moines, IA, USA?

Delta, Southwest Airlines, and two other airlines fly from General Mitchell International Airport (MKE) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to West Des Moines via Chicago and Des Moines in around 10h.

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