There are 8 ways to get from Milwaukee to Winston-Salem by plane, train, bus, car, bus (Flixbus, Greyhound), or bus (Greyhound, Flixbus, Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly General Mitchell International Airport to Piedmont Triad International Airport
best- Fly from General Mitchell International Airport (MKE) to Piedmont Triad International Airport (GSO)plane MKE - GSO
6h 22m$191–975Bus via Columbus
cheapest- Take the bus from Milwaukee Intermodal Station to Columbusbus FlixBus 2511
- Take the bus from Columbus to Winston Salem(Trans Center)bus Greyhound US0140
20h 34m$120–224Train, bus
- Take the train from Milwaukee to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Toledotrain
- Take the bus from Toledo Bus Stop to Winston Salem(Trans Center)bus
20h 28m$158–340Drive 764.3 mi
- Drive from Milwaukee to Winston-Salemcar 764.3 mi
14h 24m$140–202Bus to Chicago O'Hare International Airport, fly to Piedmont Triad International Airport
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Piedmont Triad International Airport (GSO)plane ORD - GSO
5h 55m$157–664Fly General Mitchell International Airport to Charlotte Douglas International Airport, bus
- Fly from General Mitchell International Airport (MKE) to Charlotte Douglas International Airport (CLT)plane MKE - CLT
- Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus
6h 44m$143–798Bus to Chicago O'Hare International Airport, fly to Charlotte Douglas International Airport, bus
- Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
- Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane ORD - CLT
- Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus
8h 6m$169–477Bus
- Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus
- Take the bus from Chicago Union Station to Toledobus
- Take the bus from Toledo Bus Stop to Winston Salem(Trans Center)bus
20h 42m$162–284
Milwaukee to Winston-Salem by train and bus
Questions & Answers
The cheapest way to get from Milwaukee to Winston-Salem is to bus via Columbus which costs $120 - $230 and takes 20h 34m.
The fastest way to get from Milwaukee to Winston-Salem is to bus and fly which takes 5h 55m and costs $150 - $700.
No, there is no direct bus from Milwaukee station to Winston-Salem. However, there are services departing from Milwaukee Intermodal Station and arriving at Winston Salem(Trans Center) via E Main St & S High St and Columbus. The journey, including transfers, takes approximately 20h 34m.
The distance between Milwaukee and Winston-Salem is 669 miles. The road distance is 768.7 miles.
The best way to get from Milwaukee to Winston-Salem without a car is to train and bus which takes 20h 28m and costs $150 - $340.
It takes approximately 6h 22m to get from Milwaukee to Winston-Salem, including transfers.
Milwaukee to Winston-Salem bus services, operated by Flixbus USA, depart from Milwaukee Intermodal Station.
The best way to get from Milwaukee to Winston-Salem is to fly which takes 6h 22m and costs $190 - $1,000. Alternatively, you can bus via Columbus, which costs $120 - $230 and takes 20h 34m.
Milwaukee to Winston-Salem bus services, operated by Flixbus USA, arrive at Columbus station.
Winston-Salem is 1h ahead of Milwaukee. It is currently 8:36 AM in Milwaukee and 9:36 AM in Winston-Salem.
What companies run services between Milwaukee, WI, USA and Winston-Salem, NC, USA?
Delta, American Airlines, and United Airlines fly from General Mitchell International Airport (MKE) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to Winston Salem(Trans Center) via Columbus, E Main St & S High St, S Grant Ave & E Mound St, and Columbus in around 20h 34m.
- Website
- aa.com
Flights from General Mitchell International Airport to Piedmont Triad International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $180–1,000
Flights from General Mitchell International Airport to Piedmont Triad International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $170–950
Flights from General Mitchell International Airport to Piedmont Triad International Airport via Philadelphia
- Ave. Duration
- 4h 50m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $230–1,200
Flights from Chicago O'Hare International Airport to Piedmont Triad International Airport
- Ave. Duration
- 2h 8m
- When
- Every day
- Estimated price
- $100–600
Flights from Chicago O'Hare International Airport to Piedmont Triad International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $110–650
Flights from Chicago O'Hare International Airport to Piedmont Triad International Airport via Reagan Washington
- Ave. Duration
- 4h 35m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–700
Flights from General Mitchell International Airport to Charlotte Douglas International Airport
- Ave. Duration
- 2h 6m
- When
- Every day
- Estimated price
- $130–750
Flights from Chicago O'Hare International Airport to Charlotte Douglas International Airport
- Ave. Duration
- 2h 10m
- When
- Every day
- Estimated price
- $85–480
Flights from Chicago O'Hare International Airport to Charlotte Douglas International Airport via Asheville
- Ave. Duration
- 4h 3m
- When
- Monday, Tuesday, Wednesday, Friday, and Saturday
- Estimated price
- $85–480
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Milwaukee to Chicago Union Station
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–50
- Website
- Amtrak
Train from Chicago Union Station to Toledo
- Ave. Duration
- 3h 59m
- Frequency
- 3 times a day
- Estimated price
- $60–140
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Toledo Bus Stop to Winston Salem(Trans Center)
- Ave. Duration
- 13h
- Frequency
- Once daily
- Estimated price
- $75–150
- Website
- Greyhound
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- $10–21
- Website
- Greyhound
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- $10–21
- Website
- Greyhound
Bus from Columbus to Winston Salem(Trans Center)
- Ave. Duration
- 9h 20m
- Frequency
- Once daily
- Estimated price
- $55–120
- Website
- Greyhound
Bus from Milwaukee Intermodal Station to Chicago Bus Station
- Ave. Duration
- 1h 35m
- Frequency
- 4 times a day
- Estimated price
- $12–24
- Website
- Greyhound
Bus from Toledo Bus Stop to Winston Salem(Trans Center)
- Ave. Duration
- 13h
- Frequency
- Once daily
- Estimated price
- $75–150
- Website
- Greyhound
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More Questions & Answers
Yes, the driving distance between Milwaukee to Winston-Salem is 769 miles. It takes approximately 14h 24m to drive from Milwaukee to Winston-Salem.
Book your Milwaukee to Winston-Salem bus tickets online with Omio.
There are 149+ hotels available in Winston-Salem.






