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How to get fromMinneapolis Airport (MSP) to Knoxvilleby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 6 ways to get from Minneapolis Airport (MSP) to Knoxville by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    2h 32m
    $238–997

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Asheville Regional Airport (AVL)plane plane MSP - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    4h 31m
    $121–526

  3. Train, bus

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    43h 44m
    $595–1,176

  4. Bus

    1. Take the bus from Saint Paul Union Depot to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d
    $311–488

  5. Drive 931.8 mi

    1. Drive from Minneapolis Airport (MSP) to Knoxvillecar car 931.8 mi
    15h 52m
    $171–246

  6. Train, bus via Ossining

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 19m
    $550–1,052

Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) flights

Calendar69Weekly Planes
Duration4h 19mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Minneapolis Airport (MSP) to Knoxville.ExpandLaunch map view
  • Distance: 804.5 mi
  • Duration: 2h 32m

What companies run services between Minneapolis Airport (MSP), USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from MSP Terminal 1 Transit Station to Knoxville Station Hall of Fame via Union Depot Station & Terminal, Saint Paul Union Depot, Chicago Bus Station, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 2d.

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