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How to get fromMinneapolis–Saint Paul to Knoxvilleby plane, train, bus, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Minneapolis–Saint Paul to Knoxville by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    4h 14m
    $239–1,024

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Asheville Regional Airport (AVL)plane plane MSP - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    6h 14m
    $121–539

  3. Train, bus

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    43h 47m
    $595–1,176

  4. Bus, train

    1. Take the bus from Minneapolis to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    47h
    $561–1,065

  5. Drive 929.7 mi

    1. Drive from Minneapolis–Saint Paul to Knoxvillecar car 929.7 mi
    15h 46m
    $170–246

  6. Fly to Nashville, drive

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Nashville (BNA)plane plane MSP - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 26m
    $434–1,004

  7. Train, bus via Ossining

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 21m
    $550–1,052

  8. Bus

    1. Take the bus from Saint Paul Union Depot to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d
    $311–488

Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) flights

Calendar69Weekly Planes
Duration4h 19mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Minneapolis–Saint Paul to Knoxville.ExpandLaunch map view
  • Distance: 815.6 mi
  • Duration: 4h 14m

What companies run services between Minneapolis–Saint Paul, MN, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Marshall & Otis Station to Knoxville Station Hall of Fame via Union Depot Station & Terminal, Saint Paul Union Depot, Chicago Bus Station, New York, NY, Knoxville, TN, Walmart, and Fountain City Superstop in around 2d.

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