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How to get fromMinneapolis to Knoxvilleby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus)

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There are 6 ways to get from Minneapolis to Knoxville by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    3h 53m
    $277–1,272

  2. Drive  933.3 mi

    cheapest
    1. Drive from Minneapolis to Knoxvillecar car 933.3 mi
    15h 50m
    $171–246

  3. Bus

    1. Take the bus from Minneapolis Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    43h 16m
    $399–595

  4. Train, bus

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    44h
    $905–1,455

  5. Train, bus via Ossining

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 18m
    $870–1,332

  6. Bus via Madison

    1. Take the bus from Minneapolis to Madisonbus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 1h
    $335–503

Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) flights

Calendar73Weekly Planes
Duration4h 12mAverage Duration
Ticket$225Cheapest Price
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Comparing Your Travel Options

Map of how to get from Minneapolis to Knoxville.ExpandLaunch map view
  • Distance: 812 mi
  • Duration: 3h 53m

What companies run services between Minneapolis, MN, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Minneapolis Bus Station to Knoxville via Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 43h 16m.

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