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How to get fromMinnesota to Knoxvilleby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 10 ways to get from Minnesota to Knoxville by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Minneapolis–Saint Paul International Airport to Mcghee Tyson Airport

    best
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS)plane plane MSP - TYS
    3h 51m
    $227–972

  2. Fly Minneapolis–Saint Paul International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Asheville Regional Airport (AVL)plane plane MSP - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 50m
    $124–527

  3. Bus

    1. Take the bus from Minneapolis Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    40h 11m
    $392–622

  4. Train, bus

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    44h 14m
    $625–1,176

  5. Drive 933.3 mi

    1. Drive from Minneapolis to Knoxvillecar car 933.3 mi
    15h 50m
    $171–246

  6. Fly Rochester to Mcghee Tyson Airport

    1. Fly from Rochester (RST) to Mcghee Tyson Airport (TYS)plane plane RST - TYS
    5h 40m
    $326–1,507

  7. Fly Duluth International Airport to Mcghee Tyson Airport

    1. Fly from Duluth International Airport (DLH) to Mcghee Tyson Airport (TYS)plane plane DLH - TYS
    6h 23m
    $216–872

  8. Fly Minneapolis–Saint Paul International Airport to Nashville, drive

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Nashville (BNA)plane plane MSP - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 3m
    $432–1,002

  9. Train, bus via Ossining

    1. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    44h 17m
    $580–1,102

  10. Bus, train

    1. Take the bus from U of MN Campus to Madison, WI-Lake St.bus bus
    2. Take the bus from 250 N. Lake St - Madison UW Campus to W Jackson Blvd, after S Clinton Stbus bus
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    45h 27m
    $576–1,040

Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) flights

Calendar69Weekly Planes
Duration4h 19mAverage Duration
Ticket$176Cheapest Price
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Questions & Answers

Map of how to get from Minnesota to Knoxville.ExpandLaunch map view
  • Distance: 812 mi
  • Duration: 3h 51m

What companies run services between Minnesota, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Minneapolis–Saint Paul International Airport (MSP) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Minneapolis Bus Station to Knoxville via Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 40h 11m.

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