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How to get fromMinnesota to Mayo Clinicby bus, car, or plane

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There are 4 ways to get from Minnesota to Mayo Clinic by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Minneapolis Bus Depot to Rochester, MNbus bus Minneapolis / ...
    2h 28m
    $30–45
  2. Drive 83.8 mi

    cheapest
    1. Drive from Minneapolis to Mayo Cliniccar car 83.8 mi
    1h 35m
    $16–23
  3. Fly

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Rochester (RST)plane plane MSP - RST
    3h 21m
    $38–342
  4. Bus via Terminal 2 Station

    1. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus Groome Transportation
    3h 6m
    $52

Minnesota to Mayo Clinic by bus and foot

Calendar14Weekly Services
Duration2h 28mAverage Duration
Ticket$30Cheapest Price
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Questions & Answers

What companies run services between Minnesota, USA and Mayo Clinic, MN, USA?

Jefferson Lines operates a bus from Minneapolis Bus Depot to Rochester, MN twice daily. Tickets cost $30–45 and the journey takes 2h 20m. Alternatively, Delta flies from Minneapolis–Saint Paul International Airport (MSP) to Rochester (RST) 3 times a day.

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