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How to get fromMinnesota to Mayo Clinicby bus, car, or plane

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There are 4 ways to get from Minnesota to Mayo Clinic by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Minneapolis to Rochesterbus bus Jefferson Lines 965
    2h 23m
    $30–45
  2. Drive  83.8 mi

    cheapest
    1. Drive from Minneapolis to Mayo Cliniccar car 83.8 mi
    1h 35m
    $16–23
  3. Fly

    1. Fly from Minneapolis–Saint Paul International Airport (MSP) to Rochester (RST)plane plane MSP - RST
    3h 22m
    $38–362
  4. Bus via Terminal 2 Station

    1. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus Groome Transportation
    3h 6m
    $52

Minnesota to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration2h 23mAverage Duration
Ticket$30Cheapest Price
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Questions & Answers

What companies run services between Minnesota, USA and Mayo Clinic, MN, USA?

Jefferson Lines operates a bus from Minneapolis to Rochester once daily. Tickets cost $30–45 and the journey takes 2h 15m. Alternatively, Delta flies from Minneapolis–Saint Paul International Airport (MSP) to Rochester (RST) 3 times a day.

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