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How to get fromMission Bay to Irvineby plane, bus (Flixbus), train (Amtrak), car, train, subway, bus, or bus (Greyhound)

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There are 8 ways to get from Mission Bay to Irvine by plane, bus (Flixbus), train (Amtrak), car, train, subway, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Francisco International Airport

    best
    1. Fly from San Francisco International Airport (SFO) to John Wayne Airport Orange County (SNA)plane plane SFO - SNA
    3h 4m
    $113–347

  2. BART, bus, train

    cheapest
    1. Take the subway from Powell Street to Berryessa / North San Josesubway subway
    2. Take the bus from San Jose, CA - Huong Lan Sandwich to Los Angeles, CA - Chinatown Stationbus bus
    3. Take the train from L.A. Union Station to Tustintrain train
    10h 53m
    $67–93

  3. Bus (Flixbus)

    1. Take the bus from San Francisco to Anaheim Regional Transportation Intermodal Centerbus bus FlixBus N2003
    10h 17m
    $70–101

  4. Caltrain, train

    1. Take the train from San Francisco Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train
    2. Take the train from San Jose to Los Angelestrain train
    3. Take the train from L.A. Union Station to Tustintrain train
    15h 7m
    $248–384

  5. Drive  419.8 mi

    1. Drive from Mission Bay to Irvinecar car 419.8 mi
    7h 2m
    $75–108

  6. Fly from Oakland International Airport

    1. Fly from Oakland International Airport (OAK) to John Wayne Airport Orange County (SNA)plane plane OAK - SNA
    3h 21m
    $217–760

  7. Caltrain to Norman Y. Mineta San José International Airport, fly

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to John Wayne Airport Orange County (SNA)plane plane SJC - SNA
    3h 55m
    $502–814

  8. Bus via Metro Embarcadero Station (Greyhound)

    1. Take the bus from San Francisco Bus Station to Anaheim Regional Transportation Intermodal Centerbus bus Greyhound US0831
    13h 33m
    $84–124

Mission Bay to Irvine by bus (Flixbus)

Calendar7Weekly Buses
Duration10h 17mAverage Duration
Ticket$70Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mission Bay to Irvine.ExpandLaunch map view
  • Distance: 387.6 mi
  • Duration: 3h 4m

What companies run services between Mission Bay, CA, USA and Irvine, CA, USA?

Alaska Airlines, Inc., Frontier Airlines, and United Airlines fly from San Francisco International Airport (SFO) to John Wayne Airport Orange County (SNA) hourly. Alternatively, Flixbus USA operates a bus from San Francisco to Anaheim Regional Transportation Intermodal Center once daily. Tickets cost $65–100 and the journey takes 9h 5m.

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