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How to get fromMission Bay to Santa Fe Depotby plane, train, bus, train (Amtrak), car, tram, subway, shuttle, or bus (Greyhound)

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There are 8 ways to get from Mission Bay to Santa Fe Depot by plane, train, bus, train (Amtrak), car, tram, subway, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Francisco International Airport

    best
    1. Fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN)plane plane SFO - SAN
    3h 36m
    $80–262

  2. Caltrain, bus

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train Local Weekday / ...
    2. Take the bus from San Jose - King Rd to San Ysidrobus bus San Jose
    13h 48m
    $104–149

  3. Caltrain, train

    1. Take the train from San Francisco Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train
    2. Take the train from San Jose to Los Angelestrain train
    3. Take the train from Los Angeles to San Diegotrain train
    16h 54m
    $180–377

  4. Drive 500 mi

    1. Drive from Mission Bay to Santa Fe Depotcar car 500 mi
    8h 24m
    $92–132

  5. Tram, BART to Oakland International Airport, fly

    1. Take the tram from Third Street & Mission Rock St to Union Square/Market St Station Northboundtram tram
    2. Take the subway from Powell Street to Coliseumsubway subway
    3. Fly from Oakland International Airport (OAK) to San Diego International Airport (SAN)plane plane OAK - SAN
    3h 55m
    $84–275

  6. Caltrain to Norman Y. Mineta San José International Airport, fly

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to San Diego International Airport (SAN)plane plane SJC - SAN
    4h 30m
    $84–289

  7. Shuttle to Sonoma County Airport, fly

    1. Take a shuttle bus from San Francisco Pier 27 to Santa Rosa Airportshuttle bus
    2. Fly from Sonoma County Airport (STS) to San Diego International Airport (SAN)plane plane STS - SAN
    6h 3m
    $171–314

  8. Bus

    1. Take the bus from San Francisco Bus Station to San Diego Greyhound Bus Stopbus bus Greyhound US0831
    14h 38m
    $82–162

Mission Bay to Santa Fe Depot by train, bus, and tram

Calendar14Weekly Services
Duration13h 48mAverage Duration
Ticket$104Cheapest Price
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Questions & Answers

Map of how to get from Mission Bay to Santa Fe Depot.ExpandLaunch map view
  • Distance: 467.3 mi
  • Duration: 3h 36m

What companies run services between Mission Bay, CA, USA and Santa Fe Depot, San Diego County, CA, USA?

Alaska Airlines, Inc., Frontier Airlines, and two other airlines fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN) hourly. Alternatively, you can take a train from San Francisco Caltrain Southbound to San Diego via San Jose Diridon Caltrain Southbound, San Jose, and Los Angeles in around 16h 54m.

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