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How to get fromMission Bay to Santa Fe Depotby plane, bus (Flixbus), train (Amtrak), car, tram, subway, train, shuttle, or bus (Greyhound)

Find Transport to Santa Fe Depot

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There are 8 ways to get from Mission Bay to Santa Fe Depot by plane, bus (Flixbus), train (Amtrak), car, tram, subway, train, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from San Francisco International Airport

    best
    1. Fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN)plane plane SFO - SAN
    3h 41m
    $70–222

  2. Tram, BART to Oakland International Airport, fly

    cheapest
    1. Take the tram from Third Street & Mission Rock St to Union Square/Market St Station Northboundtram tram
    2. Take the subway from Powell Street to Coliseumsubway subway
    3. Fly from Oakland International Airport (OAK) to San Diego International Airport (SAN)plane plane OAK - SAN
    4h 1m
    $64–315

  3. Bus (Flixbus)

    1. Take the bus from San Francisco to San Diegobus bus FlixBus N2003
    10h 58m
    $80–130

  4. Caltrain, train

    1. Take the train from San Francisco Caltrain Southbound to San Jose Diridon Caltrain Southboundtrain train
    2. Take the train from San Jose to Los Angelestrain train
    3. Take the train from Los Angeles to San Diegotrain train
    16h 54m
    $310–482

  5. Drive  500 mi

    1. Drive from Mission Bay to Santa Fe Depotcar car 500 mi
    8h 24m
    $89–128

  6. Caltrain to Norman Y. Mineta San José International Airport, fly

    1. Take the train from San Francisco Caltrain Southbound to Santa Clara Caltrain Southboundtrain train
    2. Fly from Norman Y. Mineta San José International Airport (SJC) to San Diego International Airport (SAN)plane plane SJC - SAN
    4h 30m
    $89–569

  7. Shuttle to Sonoma County Airport, fly

    1. Take a shuttle bus from San Francisco Pier 27 to Santa Rosa Airportshuttle bus
    2. Fly from Sonoma County Airport (STS) to San Diego International Airport (SAN)plane plane STS - SAN
    6h 4m
    $116–314

  8. Bus via Metro Embarcadero Station (Greyhound)

    1. Take the bus from San Francisco Bus Station to San Diego Greyhound Bus Stopbus bus Greyhound US0831
    14h 41m
    $97–152

Mission Bay to Santa Fe Depot by bus and tram (Flixbus)

Calendar7Weekly Services
Duration10h 58mAverage Duration
Ticket$80Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mission Bay to Santa Fe Depot.ExpandLaunch map view
  • Distance: 467.3 mi
  • Duration: 3h 41m

What companies run services between Mission Bay, CA, USA and Santa Fe Depot, San Diego County, CA, USA?

Frontier Airlines, Alaska Airlines, Inc., and two other airlines fly from San Francisco International Airport (SFO) to San Diego International Airport (SAN) hourly. Alternatively, Flixbus USA operates a bus from San Francisco to San Diego once daily. Tickets cost $80–130 and the journey takes 10h 45m.

Airlines
Train operators
Bus operators

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