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How to get fromMississauga to Durhamby plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, shuttle, train, or bus (Flixbus)

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There are 8 ways to get from Mississauga to Durham by plane, bus, bus (Greyhound, Flixbus), train (Amtrak), car, shuttle, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Toronto Pearson International Airport to Raleigh-Durham International Airport, bus, line 700 bus

    best
    1. Fly from Toronto Pearson International Airport (YYZ) to Raleigh-Durham International Airport (RDU)plane plane YYZ - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Duke St at Jackson Stbus bus
    5h 42m
    $560–1,811

  2. Bus

    cheapest
    1. Take the bus from Mississauga to Newarkbus bus Adt N809
    2. Take the bus from Newark Penn Station to Durhambus bus Greyhound US0670
    25h 39m
    $143–454

  3. Train

    1. Take the train from Oakville to New York Penn Stationtrain train VIA Rail
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Durham Amtrak Stationtrain train Carolinian
    28h 2m
    $325–696

  4. Drive 662.2 mi

    1. Drive from Mississauga to Durhamcar car 662.2 mi
    14h 9m
    $152–219

  5. Shuttle to Buffalo Niagara International Airport, fly to Raleigh-Durham International Airport

    1. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Raleigh-Durham International Airport (RDU)plane plane BUF - RDU
    7h 7m
    $195–681

  6. Fly Toronto Island Airport to Raleigh-Durham International Airport

    1. Fly from Toronto Island Airport (YTZ) to Raleigh-Durham International Airport (RDU)plane plane YTZ - RDU
    8h 22m
    $562–1,814

  7. Fly Toronto Pearson International Airport to Piedmont Triad International Airport, train

    1. Fly from Toronto Pearson International Airport (YYZ) to Piedmont Triad International Airport (GSO)plane plane YYZ - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    9h 3m
    $146–630

  8. Bus via Washington

    1. Take the bus from Toronto to Ithacabus bus
    2. Take the bus from Ithaca to Washington Union Stationbus bus
    3. Take the bus from Washington, DC - 2305 Pennsylvania Ave to Durham, NC - 3446 Hillsborough Rdbus bus
    27h 29m
    $153–275

Mississauga to Durham by bus

Calendar11Weekly Buses
Duration25h 39mAverage Duration
Ticket$143Cheapest Price
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Questions & Answers

Map of how to get from Mississauga to Durham.ExpandLaunch map view
  • Distance: 567.9 mi
  • Duration: 5h 42m

What companies run services between Mississauga, ON, Canada and Durham, NC, USA?

You can take a bus from City Centre Transit Terminal Platform O to Durham via Mississauga and Newark Penn Station in around 25h 39m. Alternatively, you can take a bus from Square One to Durham Amtrak Station via Oakville GO Bus, Oakville, Penn Station, and Ny Moynihan Train Hall At Penn Station in around 28h 2m.

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