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How to get fromMississauga to Knoxvilleby plane, bus (Flixbus), train, bus, or car

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There are 9 ways to get from Mississauga to Knoxville by plane, bus (Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Toronto Pearson International Airport to Mcghee Tyson Airport

    best
    1. Fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS)plane plane YYZ - TYS
    7h 4m
    $229–1,024

  2. Fly Toronto Pearson International Airport to Nashville, drive

    cheapest
    1. Fly from Toronto Pearson International Airport (YYZ) to Nashville (BNA)plane plane YYZ - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 30m
    $103–449

  3. Bus

    1. Take the bus from Toronto Pearson Airport to New York Midtownbus bus FlixBus N2768a / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    24h 58m
    $267–377

  4. Train, bus

    1. Take the train from Toronto Union Station to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    28h 9m
    $283–499

  5. Train, bus via Farragut

    1. Take the train from Toronto Union Station to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    28h 22m
    $327–588

  6. Fly Toronto Island Airport to Mcghee Tyson Airport

    1. Fly from Toronto Island Airport (YTZ) to Mcghee Tyson Airport (TYS)plane plane YTZ - TYS
    7h 40m
    $251–1,190

  7. Bus to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport

    1. Take the bus from Mississauga to Buffalobus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    9h 45m
    $259–1,134

  8. Bus via Toronto

    1. Take the bus from Toronto to New Yorkbus bus Adt N813-D / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    26h 39m
    $257–598

  9. Drive  721.2 mi

    1. Drive from Mississauga to Knoxvillecar car 721.2 mi
    12h 7m
    $149–215

Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS) flights

Calendar104Weekly Planes
Duration5h 12mAverage Duration
Ticket$172Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Mississauga to Knoxville.ExpandLaunch map view
  • Distance: 614.5 mi
  • Duration: 7h 4m

What companies run services between Mississauga, ON, Canada and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Square One to Knoxville via Pearson International Airport Terminal 1, Toronto Pearson Airport, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 24h 58m.

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