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How to get fromMississauga to Knoxvilleby plane, bus (Flixbus), train, bus, car, or shuttle

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There are 9 ways to get from Mississauga to Knoxville by plane, bus (Flixbus), train, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Toronto Pearson International Airport to Mcghee Tyson Airport

    best
    1. Fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS)plane plane YYZ - TYS
    6h 50m
    $169–675

  2. Drive 722.1 mi

    cheapest
    1. Drive from Mississauga to Knoxvillecar car 722.1 mi
    12h 25m
    $166–239

  3. Bus via Union Station Bus Terminal

    1. Take the bus from Toronto to New York Midtownbus bus FlixBus N2768a / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    25h 27m
    $268–399

  4. Train, bus

    1. Take the train from Oakville to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    27h 46m
    $283–489

  5. Fly Toronto Island Airport to Mcghee Tyson Airport

    1. Fly from Toronto Island Airport (YTZ) to Mcghee Tyson Airport (TYS)plane plane YTZ - TYS
    7h 55m
    $201–778

  6. Shuttle to Buffalo Niagara International Airport, fly to Mcghee Tyson Airport

    1. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Mcghee Tyson Airport (TYS)plane plane BUF - TYS
    8h 3m
    $339–1,195

  7. Fly Toronto Pearson International Airport to Nashville, drive

    1. Fly from Toronto Pearson International Airport (YYZ) to Nashville (BNA)plane plane YYZ - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 19m
    $174–1,355

  8. Bus

    1. Take the bus from Mississauga to New Yorkbus bus Adt N801 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    26h 9m
    $251–567

  9. Train, bus via Union Station Bus Terminal

    1. Take the train from Toronto Union Station to New York Penn Stationtrain train VIA Rail
    2. Take the bus from New York to Knoxvillebus bus Nyc
    28h 22m
    $328–589

Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS) flights

Calendar145Weekly Planes
Duration5h 30mAverage Duration
Ticket$118Cheapest Price
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Questions & Answers

Map of how to get from Mississauga to Knoxville.ExpandLaunch map view
  • Distance: 614.5 mi
  • Duration: 6h 50m

What companies run services between Mississauga, ON, Canada and Knoxville, TN, USA?

Delta, United Airlines, and American Airlines fly from Toronto Pearson International Airport (YYZ) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from Rathburn Rd. W. @ Mavis Rd. to Knoxville via Union Station Bus Terminal, Toronto, New York Midtown, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 25h 27m.

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