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How to get fromMississauga to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car, shuttle, or bus (Greyhound)

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There are 8 ways to get from Mississauga to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Toronto Pearson International Airport

    best
    1. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    5h 15m
    $97–488

  2. Bus via Indianapolis

    1. Take the bus from Mississauga to Detroit Bus Stationbus bus
    2. Take the bus from Detroit, MI to Indianapolis, INbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    17h 20m
    $98–203

  3. Train via Detroit

    1. Take the train from Oakville to Windsortrain train
    2. Take the train from Detroit to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    17h 39m
    $236–599

  4. Drive 732.1 mi

    1. Drive from Mississauga to St. Louiscar car 732.1 mi
    12h 43m
    $168–242

  5. Shuttle to Buffalo Niagara International Airport, fly

    1. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    8h 18m
    $247–928

  6. Fly from Toronto Island Airport

    1. Fly from Toronto Island Airport (YTZ) to Lambert–St. Louis International Airport (STL)plane plane YTZ - STL
    7h 54m
    $489–961

  7. Train

    1. Take the train from Oakville to Buffalotrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    22h 40m
    $290–716

  8. Bus

    1. Take the bus from Mississauga to Buffalobus bus
    2. Take the bus from Buffalo, Ny to Pittsburgh, Pabus bus 530
    3. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus
    26h 24m
    $168–459

Mississauga to St. Louis by bus

Calendar5Weekly Buses
Duration17h 20mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from Mississauga to St. Louis.ExpandLaunch map view
  • Distance: 678.2 mi
  • Duration: 5h 15m

What companies run services between Mississauga, ON, Canada and St. Louis, MO, USA?

Air Canada, United Airlines, and two other airlines fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Mississauga to St Louis Bus Station via Detroit, MI and Indianapolis Union Station in around 17h 20m.

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