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How to get fromMississippi to Des Moinesby plane, bus (Greyhound), train, bus, or car

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There are 7 ways to get from Mississippi to Des Moines by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Memphis

    best
    1. Fly from Memphis (MEM) to Des Moines (DSM)plane plane MEM - DSM
    4h 22m
    $209–947

  2. Drive  805.6 mi

    cheapest
    1. Drive from Jackson to Des Moinescar car 805.6 mi
    14h 15m
    $147–213

  3. Bus

    1. Take the bus from Jackson to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    3. Take the bus from Kansas City to Des Moinesbus bus
    19h 30m
    $163–295

  4. Train, bus

    1. Take the train from Jackson to Champaign-Urbanatrain train City of New Orleans
    2. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus Greyhound US0157S
    21h 30m
    $213–461

  5. Fly from Gulfport-Biloxi Regional Airport

    1. Fly from Gulfport-Biloxi Regional Airport (GPT) to Des Moines (DSM)plane plane GPT - DSM
    4h 45m
    $217–982

  6. Fly from Jackson/Vicksburg

    1. Fly from Jackson/Vicksburg (JAN) to Des Moines (DSM)plane plane JAN - DSM
    5h 6m
    $216–867

  7. Fly from Meridian

    1. Fly from Meridian (MEI) to Des Moines (DSM)plane plane MEI - DSM
    6h 15m
    $213–890

Mississippi to Des Moines by bus

Calendar7Weekly Buses
Duration19h 30mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Mississippi to Des Moines.ExpandLaunch map view
  • Distance: 503.6 mi
  • Duration: 4h 22m

What companies run services between Mississippi, USA and Des Moines, IA, USA?

Southwest Airlines, Delta, and two other airlines fly from Memphis (MEM) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Jackson to Des Moines via St Louis Bus Station, Kansas City Bus Station, and Kansas City in around 19h 30m.

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