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How to get fromMississippi to Florida Keysby plane, bus (Greyhound, Flixbus), car, shuttle, train, or bus

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There are 8 ways to get from Mississippi to Florida Keys by plane, bus (Greyhound, Flixbus), car, shuttle, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Gulfport-Biloxi Regional Airport to Key West International Airport

    best
    1. Fly from Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW)plane plane GPT - EYW
    7h 57m
    $172–515

  2. Bus

    cheapest
    1. Take the bus from Jackson to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    28h 50m
    $171–334

  3. Drive 1,028.8 mi

    1. Drive from Jackson to Florida Keyscar car 1,028.8 mi
    18h 28m
    $188–272

  4. Fly Memphis to Key West International Airport

    1. Fly from Memphis (MEM) to Key West International Airport (EYW)plane plane MEM - EYW
    7h 17m
    $189–570

  5. Fly Jackson/Vicksburg to Key West International Airport

    1. Fly from Jackson/Vicksburg (JAN) to Key West International Airport (EYW)plane plane JAN - EYW
    7h 22m
    $181–480

  6. Fly Memphis to Miami International Airport, shuttle

    1. Fly from Memphis (MEM) to Miami International Airport (MIA)plane plane MEM - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 10m
    $284–810

  7. Fly Memphis to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Memphis (MEM) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MEM - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 31m
    $304–830

  8. Train, bus, shuttle

    1. Take the train from Jackson to New Orleans Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    3. Take the bus from Gulfport to Miamibus bus
    4. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    29h 40m
    $371–545

Mississippi to Florida Keys by bus and foot

Calendar14Weekly Services
Duration28h 50mAverage Duration
Ticket$171Cheapest Price
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Questions & Answers

Map of how to get from Mississippi to Florida Keys.ExpandLaunch map view
  • Distance: 627.7 mi
  • Duration: 7h 57m

What companies run services between Mississippi, USA and Florida Keys, FL, USA?

Delta and American Airlines fly from Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW) 4 times a day. Alternatively, you can take a bus from Jackson to Florida Keys via Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 28h 50m.

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