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How to get fromMississippi to South Carolinaby plane, taxi, bus (Greyhound), or car

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There are 7 ways to get from Mississippi to South Carolina by plane, taxi, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Memphis to Charlotte Douglas International Airport, taxi

    best
    1. Fly from Memphis (MEM) to Charlotte Douglas International Airport (CLT)plane plane MEM - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    2h 35m
    $222–826

  2. Drive 668.7 mi

    cheapest
    1. Drive from Jackson to Charlestoncar car 668.7 mi
    11h 41m
    $122–177

  3. Bus (Greyhound)

    1. Take the bus from Jackson to Atlanta Bus Stationbus bus Greyhound US0604
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    22h 19m
    $133–255

  4. Fly Gulfport-Biloxi Regional Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Gulfport-Biloxi Regional Airport (GPT) to Charlotte Douglas International Airport (CLT)plane plane GPT - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    2h 39m
    $210–811

  5. Fly Jackson/Vicksburg to Charlotte Douglas International Airport, taxi

    1. Fly from Jackson/Vicksburg (JAN) to Charlotte Douglas International Airport (CLT)plane plane JAN - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    2h 56m
    $214–696

  6. Fly Memphis to Columbia

    1. Fly from Memphis (MEM) to Columbia (CAE)plane plane MEM - CAE
    4h 54m
    $224–1,228

  7. Drive to Northwest Alabama Regional Airport, fly to Charlotte Douglas International Airport, taxi

    1. Drive from Tupelo to Northwest Alabama Regional Airport (MSL)car car
    2. Fly from Northwest Alabama Regional Airport (MSL) to Charlotte Douglas International Airport (CLT)plane plane MSL - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 1m
    $275–822

Mississippi to South Carolina by bus (Greyhound)

Calendar14Weekly Buses
Duration22h 19mAverage Duration
Ticket$133Cheapest Price
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Questions & Answers

Map of how to get from Mississippi to South Carolina.ExpandLaunch map view
  • Distance: 545.3 mi
  • Duration: 2h 35m

What companies run services between Mississippi, USA and South Carolina, USA?

You can take a bus from Jackson to Transit Mall via Atlanta Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 22h 19m. Alternatively, Delta, American Airlines, and United Airlines fly from Memphis (MEM) to Columbia (CAE) hourly.

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