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How to get fromMississippi to St. Louisby plane, bus (Greyhound), train, bus, or car

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There are 4 ways to get from Mississippi to St. Louis by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Memphis (MEM) to Lambert–St. Louis International Airport (STL)plane plane MEM - STL
    3h 59m
    $135–679

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Jackson to St Louis Bus Stationbus bus Greyhound US1173
    10h 5m
    $80–160

  3. Train, bus

    1. Take the train from Jackson to Carbondaletrain train City of New Orleans
    2. Take the bus from Carbondale to St. Louisbus bus Amtrak Thruway Connecting Service
    12h 33m
    $159–339

  4. Drive 490.5 mi

    1. Drive from Jackson to St. Louiscar car 490.5 mi
    7h 56m
    $90–130

Mississippi to St. Louis by bus (Greyhound)

Calendar7Weekly Buses
Duration10h 5mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Mississippi to St. Louis.ExpandLaunch map view
  • Distance: 277 mi
  • Duration: 3h 59m

What companies run services between Mississippi, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Memphis (MEM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Jackson to St Louis Bus Station once daily. Tickets cost $80–160 and the journey takes 10h 5m.

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