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How to get fromMississippi to St. Louisby plane, bus (Greyhound), train, bus, or car

Find Transport to St. Louis

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There are 5 ways to get from Mississippi to St. Louis by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Memphis

    best
    1. Fly from Memphis (MEM) to Lambert–St. Louis International Airport (STL)plane plane MEM - STL
    4h 39m
    $125–629

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Jackson to St Louis Bus Stationbus bus Greyhound US1173
    10h 5m
    $90–140

  3. Train, bus

    1. Take the train from Jackson to Carbondaletrain train City of New Orleans
    2. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus FlixBus N2521
    12h 28m
    $257–394

  4. Drive  490.5 mi

    1. Drive from Jackson to St. Louiscar car 490.5 mi
    7h 56m
    $90–130

  5. Fly from Jackson/Vicksburg

    1. Fly from Jackson/Vicksburg (JAN) to Lambert–St. Louis International Airport (STL)plane plane JAN - STL
    4h 31m
    $132–599

Mississippi to St. Louis by bus (Greyhound)

Calendar7Weekly Buses
Duration10h 5mAverage Duration
Ticket$90Cheapest Price
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Comparing Your Travel Options

Map of how to get from Mississippi to St. Louis.ExpandLaunch map view
  • Distance: 277 mi
  • Duration: 4h 39m

What companies run services between Mississippi, USA and St. Louis, MO, USA?

Delta, Southwest Airlines, and two other airlines fly from Memphis (MEM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Jackson to St Louis Bus Station once daily. Tickets cost $90–140 and the journey takes 10h 5m.

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