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How to get fromMissoula to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 8 ways to get from Missoula to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Missoula International Airport (MSO) to Mcghee Tyson Airport (TYS)plane plane MSO - TYS
    7h 39m
    $405–1,270

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Missoula International Airport (MSO) to Asheville Regional Airport (AVL)plane plane MSO - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    10h 1m
    $222–835

  3. Bus

    1. Take the bus from Missoula to Billingsbus bus
    2. Take the bus from Billings to Minneapolisbus bus
    3. Take the bus from Minneapolis Bus Station to Chicago Bus Stationbus bus
    4. Take the bus from Chicago Bus Station to New York Midtownbus bus
    5. Take the bus from New York to Knoxvillebus bus
    2d 14h
    $652–998

  4. Bus, train

    1. Take the bus from Missoula to Spokanebus bus
    2. Take the train from Spokane to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus
    3d 5h
    $1,146–2,276

  5. Drive 2,068 mi

    1. Drive from Missoula to Knoxvillecar car 2,068 mi
    33h 38m
    $378–546

  6. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Missoula International Airport (MSO) to Chattanooga Metropolitan Airport (CHA)plane plane MSO - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    9h 39m
    $378–1,528

  7. Bus, train via Ossining

    1. Take the bus from Missoula to Spokanebus bus
    2. Take the train from Spokane to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    4. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    5. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 5h
    $1,101–2,203

  8. Bus, train #2

    1. Take the bus from Missoula to Spokanebus bus
    2. Take the train from Spokane to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    4. Take the bus from New York, NY to Knoxville, TNbus bus
    3d 9h
    $912–1,758

Missoula International Airport (MSO) to Mcghee Tyson Airport (TYS) flights

Calendar54Weekly Planes
Duration7h 31mAverage Duration
Ticket$358Cheapest Price
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Questions & Answers

Map of how to get from Missoula to Knoxville.ExpandLaunch map view
  • Distance: 1,746.5 mi
  • Duration: 7h 39m

What companies run services between Missoula, MT, USA and Knoxville, TN, USA?

United Airlines, American Airlines, and three other airlines fly from Missoula International Airport (MSO) to Mcghee Tyson Airport (TYS) every 4 hours. Alternatively, you can take a bus from Missoula to Knoxville via Billings, Minneapolis Bus Station, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 2d 14h.

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