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How to get fromMissouri to La Crosseby plane, bus, train (Amtrak), car, or bus (Greyhound)

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There are 8 ways to get from Missouri to La Crosse by plane, bus, train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia Regional Airport

    best
    1. Fly from Columbia Regional Airport (COU) to La Crosse (LSE)plane plane COU - LSE
    6h 7m
    $134–449

  2. Drive  430.4 mi

    cheapest
    1. Drive from Kansas City to La Crossecar car 430.4 mi
    8h 11m
    $79–114

  3. Bus

    1. Take the bus from Kansas City to St. Paulbus bus Jefferson Lines 802 / ...
    2. Take the bus from St. Paul to La Crossebus bus Jefferson Lines 965
    12h 45m
    $144–208

  4. Train (Amtrak)

    1. Take the train from Kansas City to Chicago Union Stationtrain train Southwest Chief / ...
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    14h 46m
    $194–502

  5. Fly from Springfield-Branson National Airport

    1. Fly from Springfield-Branson National Airport (SGF) to La Crosse (LSE)plane plane SGF - LSE
    5h 7m
    $105–432

  6. Fly from Lambert–St. Louis International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to La Crosse (LSE)plane plane STL - LSE
    5h 40m
    $86–426

  7. Fly from Kansas City

    1. Fly from Kansas City (MCI) to La Crosse (LSE)plane plane MCI - LSE
    6h 31m
    $109–573

  8. Bus via Des Moines

    1. Take the bus from Kansas City Bus Station to Des Moinesbus bus
    2. Take the bus from Des Moines to Minneapolis Bus Stationbus bus
    3. Take the bus from Minneapolis to La Crossebus bus
    13h 45m
    $111–179

Missouri to La Crosse by bus

Calendar7Weekly Buses
Duration12h 45mAverage Duration
Ticket$144Cheapest Price
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Comparing Your Travel Options

Map of how to get from Missouri to La Crosse.ExpandLaunch map view
  • Distance: 373.9 mi
  • Duration: 6h 7m

What companies run services between Missouri, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Columbia Regional Airport (COU) to La Crosse (LSE) every 4 hours. Alternatively, you can take a bus from Kansas City to La Crosse via St. Paul in around 12h 45m.

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