There are 7 ways to get from Missouri to La Crosse by plane, bus, train (Amtrak), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Columbia Regional Airport
best- Fly from Columbia Regional Airport (COU) to La Crosse (LSE)plane COU - LSE
5h 40m$134–439Drive 430.4 mi
cheapest- Drive from Kansas City to La Crossecar 430.4 mi
8h 11m$79–114Bus
- Take the bus from Kansas City to Albert Leabus
- Take the bus from Albert Lea to Rochesterbus
- Take the bus from Rochester, MN to La Crossebus
11h 50mTrain (Amtrak)
- Take the train from Kansas City to Chicago Union Stationtrain Southwest Chief / ...
- Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain Empire Builder / ...
14h 46m$232–474Fly from Springfield-Branson National Airport
- Fly from Springfield-Branson National Airport (SGF) to La Crosse (LSE)plane SGF - LSE
4h 37m$105–412Fly from Lambert–St. Louis International Airport
- Fly from Lambert–St. Louis International Airport (STL) to La Crosse (LSE)plane STL - LSE
5h 36m$96–466Fly from Kansas City
- Fly from Kansas City (MCI) to La Crosse (LSE)plane MCI - LSE
6h 50m$114–573
Columbia Regional Airport (COU) to La Crosse (LSE) flights
Questions & Answers
The cheapest way to get from Missouri to La Crosse is to drive which costs $75 - $120 and takes 8h 11m.
The fastest way to get from Missouri to La Crosse is to fly which takes 4h 37m and costs $100 - $420.
No, there is no direct bus from Missouri to La Crosse. However, there are services departing from Kansas City and arriving at La Crosse via Albert Lea and Rochester, MN. The journey, including transfers, takes approximately 11h 50m.
No, there is no direct train from Missouri to La Crosse station. However, there are services departing from Metro Center and arriving at La Crosse Amtrak Station via Kansas City and Chicago Union Station. The journey, including transfers, takes approximately 14h 46m.
The distance between Missouri and La Crosse is 376 miles. The road distance is 432.9 miles.
The best way to get from Missouri to La Crosse without a car is to bus which takes 11h 50m and costs .
It takes approximately 5h 40m to get from Missouri to La Crosse, including transfers.
Missouri to La Crosse bus services, operated by Jefferson Lines, depart from Kansas City station.
Missouri to La Crosse train services, operated by Amtrak, depart from Kansas City station.
The best way to get from Missouri to La Crosse is to fly which takes 5h 40m and costs $130 - $440. Alternatively, you can bus, which costs and takes 11h 50m, you could also train, which costs $230 - $480 and takes 14h 46m.
What companies run services between Missouri, USA and La Crosse, WI, USA?
American Airlines and United Airlines fly from Columbia Regional Airport (COU) to La Crosse (LSE) 4 times a day. Alternatively, you can take a bus from Kansas City to La Crosse via Albert Lea and Rochester, MN in around 11h 50m.
- Website
- aa.com
Flights from Columbia Regional Airport to La Crosse via Chicago O'Hare
- Ave. Duration
- 6h 13m
- When
- Every day
- Estimated price
- $60–350
Flights from Springfield-Branson National Airport to La Crosse via Chicago O'Hare
- Ave. Duration
- 4h 34m
- When
- Every day
- Estimated price
- $70–370
Flights from Springfield-Branson National Airport to La Crosse via Dallas/Ft.Worth, Chicago O'Hare
- Ave. Duration
- 8h 4m
- When
- Every day
- Estimated price
- $120–550
Flights from Springfield-Branson National Airport to La Crosse via Charlotte, Chicago O'Hare
- Ave. Duration
- 8h 42m
- When
- Every day
- Estimated price
- $130–550
Flights from Lambert–St. Louis International Airport to La Crosse via Chicago O'Hare
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $75–440
Flights from Kansas City to La Crosse via Chicago O'Hare
- Ave. Duration
- 5h 24m
- When
- Every day
- Estimated price
- $95–550
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Kansas City to Chicago Union Station
- Ave. Duration
- 7h 41m
- Frequency
- Twice daily
- Estimated price
- $140–290
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to La Crosse Amtrak Station
- Ave. Duration
- 4h 59m
- Frequency
- 3 times a day
- Estimated price
- $90–190
- Website
- https://www.amtrak.com/home.html
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Kansas City to Albert Lea
- Ave. Duration
- 6h 45m
- Frequency
- 3 times a day
- Estimated price
- $80–120
- Book at
- https://www.jeffersonlines.com
- Adult
- $80–120
Bus from Rochester, MN to La Crosse
- Ave. Duration
- 1h 35m
- Frequency
- 3 times a day
- Estimated price
- $28–40
- Book at
- https://www.jeffersonlines.com
- Adult
- $28–40
- Website
- example.com
Bus from Albert Lea to Rochester
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Schedules at
- example.com
Want to know more about travelling around United States
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More Questions & Answers
Missouri to La Crosse bus services, operated by Jefferson Lines, arrive at Albert Lea station.
Missouri to La Crosse train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Missouri to La Crosse is 433 miles. It takes approximately 8h 11m to drive from Missouri to La Crosse.
There are 45+ hotels available in La Crosse.









