There are 6 ways to get from Missouri to Mayo Clinic by bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Kansas City to Owatonnabus Jefferson Lines 802 / ...
- Take the bus from Owatonna to Rochesterbus Lta 239 / ...
9h 8m$96–165Drive 399 mi
cheapest- Drive from Kansas City to Mayo Cliniccar 399 mi
6h 39m$73–106Fly Lambert–St. Louis International Airport to Rochester
- Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane STL - RST
7h 5m$74–452Fly Kansas City to Rochester
- Fly from Kansas City (MCI) to Rochester (RST)plane MCI - RST
7h 28m$76–510Fly Lambert–St. Louis International Airport to Minneapolis–Saint Paul International Airport, bus
- Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane STL - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
5h 54m$434–1,004Fly Kansas City to Minneapolis–Saint Paul International Airport, bus
- Fly from Kansas City (MCI) to Minneapolis–Saint Paul International Airport (MSP)plane MCI - MSP
- Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
6h 14m$492–1,002
Missouri to Mayo Clinic by bus and foot
Comparing Your Travel Options
The cheapest way to get from Missouri to Mayo Clinic is to drive which costs $70 - $110 and takes 6h 39m.
The fastest way to get from Missouri to Mayo Clinic is to fly and bus which takes 5h 54m and costs $430 - $1,000.
No, there is no direct bus from Missouri to Mayo Clinic. However, there are services departing from Kansas City and arriving at Rochester via Owatonna. The journey, including transfers, takes approximately 9h 8m.
The distance between Missouri and Mayo Clinic is 424 miles. The road distance is 401.3 miles.
The best way to get from Missouri to Mayo Clinic without a car is to bus which takes 9h 8m and costs $95 - $170.
It takes approximately 9h 8m to get from Missouri to Mayo Clinic, including transfers.
Missouri to Mayo Clinic bus services, operated by Jefferson Lines, depart from Kansas City station.
The best way to get from Missouri to Mayo Clinic is to bus which takes 9h 8m and costs $95 - $170. Alternatively, you can fly, which costs $70 - $460 and takes 7h 5m.
Missouri to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Owatonna station.
Yes, the driving distance between Missouri to Mayo Clinic is 401 miles. It takes approximately 6h 39m to drive from Missouri to Mayo Clinic.
What companies run services between Missouri, USA and Mayo Clinic, MN, USA?
You can take a bus from Kansas City to Mayo Clinic via Owatonna and Rochester in around 9h 8m. Alternatively, American Airlines, Delta, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Rochester (RST) every 4 hours.
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 4h 38m
- When
- Every day
- Estimated price
- $70–410
Flights from Kansas City to Rochester via Minneapolis–Saint Paul International Airport
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $75–470
Flights from Lambert–St. Louis International Airport to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 1h 39m
- When
- Every day
- Estimated price
- $80–490
Flights from Kansas City to Minneapolis–Saint Paul International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $90–550
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Kansas City to Owatonna
- Ave. Duration
- 7h 15m
- Frequency
- 3 times a day
- Estimated price
- $90–130
- Book at
- Jefferson Lines
- Adult
- $90–130
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Booking & Getting There
There are 78+ hotels available in Mayo Clinic.