What is the cheapest way to get from Missouri to Mayo Clinic?

The cheapest way to get from Missouri to Mayo Clinic is to drive which costs $70 - $110 and takes 6h 39m.

What is the fastest way to get from Missouri to Mayo Clinic?

The fastest way to get from Missouri to Mayo Clinic is to fly and bus which takes 6h 16m and costs $130 - $600.

Is there a direct bus between Missouri and Mayo Clinic?

No, there is no direct bus from Missouri to Mayo Clinic. However, there are services departing from Kansas City and arriving at Rochester via St. Paul. The journey, including transfers, takes approximately 10h 56m.

How far is it from Missouri to Mayo Clinic?

The distance between Missouri and Mayo Clinic is 526 miles. The road distance is 401.4 miles.

How do I travel from Missouri to Mayo Clinic without a car?

The best way to get from Missouri to Mayo Clinic without a car is to bus which takes 10h 56m and costs $130 - $190.

How long does it take to get from Missouri to Mayo Clinic?

It takes approximately 10h 56m to get from Missouri to Mayo Clinic, including transfers.

Where do I catch the Missouri to Mayo Clinic bus from?

Missouri to Mayo Clinic bus services, operated by Jefferson Lines, depart from Kansas City station.

Bus or fly from Missouri to Mayo Clinic?

The best way to get from Missouri to Mayo Clinic is to bus which takes 10h 56m and costs $130 - $190. Alternatively, you can fly, which costs $80 - $550 and takes 6h 57m.

Where does the Missouri to Mayo Clinic bus arrive?

Missouri to Mayo Clinic bus services, operated by Jefferson Lines, arrive at St. Paul station.

Can I drive from Missouri to Mayo Clinic?

Yes, the driving distance between Missouri to Mayo Clinic is 401 miles. It takes approximately 6h 39m to drive from Missouri to Mayo Clinic.

Where can I stay near Mayo Clinic?

There are 76+ hotels available in Mayo Clinic.

Missouri to Mayo Clinic - 7 ways to travel via bus, car, and plane

How to get fromMissouri to Mayo Clinic

Travel from

See all options

Search accommodation with Expedia

There are 7 ways to get from Missouri to Mayo Clinic by bus, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus
best
1. Take the bus from Kansas City to St. Paulbus Jefferson Lines 802 / ...
2. Take the bus from St. Paul to Rochesterbus Jefferson Lines 965
10h 56m
$132–183
Drive 399.1 mi
cheapest
1. Drive from Kansas City to Mayo Cliniccar 399.1 mi
6h 39m
$71–102
Fly Kansas City to Rochester
1. Fly from Kansas City (MCI) to Rochester (RST)plane MCI - RST
6h 57m
$81–530
Bus via Des Moines
1. Take the bus from Kansas City Bus Station to Des Moinesbus
2. Take the bus from Des Moines to Minneapolis Bus Stationbus
3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
12h 25m
$133–175
Fly Lambert–St. Louis International Airport to Rochester
1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane STL - RST
6h 45m
$74–472
Fly Lambert–St. Louis International Airport to Minneapolis–Saint Paul International Airport, bus
1. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane STL - MSP
2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
6h 16m
$138–602
Fly Kansas City to Minneapolis–Saint Paul International Airport, bus
1. Fly from Kansas City (MCI) to Minneapolis–Saint Paul International Airport (MSP)plane MCI - MSP
2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus
6h 31m
$490–1,150

Missouri to Mayo Clinic by bus and foot

7Weekly Services

10h 56mAverage Duration

$132Cheapest Price

See schedules

Comparing Your Travel Options

Map of how to get from Missouri to Mayo Clinic.

Launch map view

Distance: 522.6 mi
Duration: 10h 56m

What companies run services between Missouri, USA and Mayo Clinic, MN, USA?

You can take a bus from Kansas City to Mayo Clinic via St. Paul and Rochester in around 10h 56m. Alternatively, Delta, American Airlines, and United Airlines fly from Kansas City (MCI) to Rochester (RST) 4 times a day.

Airlines

Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Travelling to the US: What do I need to know?

Rome2Rio’s travel guides to the US tell you the best ways to explore the country, from Amtrak to Greyhound to the New York Subway.

Read the travel guide Travelling to the US: What do I need to know?

Need to know: Greyhound

Rome2Rio’s guide on the bus operator has all the information you need

Read the travel guide Need to know: Greyhound

How to get fromMissouri to Mayo Clinicby bus, car, plane, or bus (Greyhound)

There are 7 ways to get from Missouri to Mayo Clinic by bus, car, plane, or bus (Greyhound)

Bus

Drive 399.1 mi

Fly Kansas City to Rochester

Bus via Des Moines

Fly Lambert–St. Louis International Airport to Rochester

Fly Lambert–St. Louis International Airport to Minneapolis–Saint Paul International Airport, bus

Fly Kansas City to Minneapolis–Saint Paul International Airport, bus