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How to get fromMissouri to Mayo Clinicby bus, car, or plane

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There are 6 ways to get from Missouri to Mayo Clinic by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Kansas City to Albert Leabus bus Jefferson Lines 802 / ...
    2. Take the bus from Albert Lea to Rochesterbus bus Lta 235
    9h 23m

  2. Drive 399 mi

    cheapest
    1. Drive from Kansas City to Mayo Cliniccar car 399 mi
    6h 39m
    $73–106

  3. Fly Lambert–St. Louis International Airport to Rochester

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane plane STL - RST
    6h 47m
    $82–452

  4. Fly Kansas City to Rochester

    1. Fly from Kansas City (MCI) to Rochester (RST)plane plane MCI - RST
    6h 52m
    $80–470

  5. Fly Lambert–St. Louis International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 54m
    $434–1,004

  6. Fly Kansas City to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Kansas City (MCI) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCI - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 16m
    $652–1,002

Lambert–St. Louis International Airport (STL) to Rochester (RST) flights

Calendar54Weekly Planes
Duration5h 6mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from Missouri to Mayo Clinic.ExpandLaunch map view
  • Distance: 411.9 mi
  • Duration: 9h 23m

What companies run services between Missouri, USA and Mayo Clinic, MN, USA?

You can take a bus from Kansas City to Mayo Clinic via Albert Lea and Rochester in around 9h 23m. Alternatively, American Airlines, United Airlines, and Delta fly from Lambert–St. Louis International Airport (STL) to Rochester (RST) every 4 hours.

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