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How to get fromMobile to Columbiaby plane, bus (Greyhound), train (Amtrak), car, train, or bus

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There are 7 ways to get from Mobile to Columbia by plane, bus (Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Mobile Regional Airport

    best
    1. Fly from Mobile Regional Airport (MOB) to Columbia (CAE)plane plane MOB - CAE
    8h 21m
    $152–822

  2. Drive 532.6 mi

    cheapest
    1. Drive from Mobile to Columbiacar car 532.6 mi
    8h 43m
    $98–141

  3. Bus

    1. Take the bus from Mobile Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    15h 33m
    $123–221

  4. Train (Amtrak)

    1. Take the train from Mobile, AL to New Orleans, LA - Union Passenger Terminaltrain train
    2. Take the train from New Orleans Union Passenger Terminal to Greensborotrain train
    3. Take the train from Greensboro to Carytrain train
    4. Take the train from Cary to Columbia Stationtrain train
    33h 31m
    $393–869

  5. Train to Gulfport-Biloxi Regional Airport, fly

    1. Take the train from Mobile Amtrak Sta to Gulfport Amtrak Statrain train
    2. Fly from Gulfport-Biloxi Regional Airport (GPT) to Columbia (CAE)plane plane GPT - CAE
    7h 49m
    $230–1,167

  6. Bus to Pensacola International Airport, fly

    1. Take the bus from Mobile Bus Station to Pensacola Airportbus bus
    2. Fly from Pensacola International Airport (PNS) to Columbia (CAE)plane plane PNS - CAE
    9h 4m
    $132–770

  7. Bus, train

    1. Take the bus from Mobile to Tallahasseebus bus
    2. Take the bus from Tallahassee to Jacksonvillebus bus
    3. Take the train from Jacksonville to Columbia Stationtrain train
    16h 27m
    $184–326

Mobile Regional Airport (MOB) to Columbia (CAE) flights

Calendar50Weekly Planes
Duration5h 10mAverage Duration
Ticket$149Cheapest Price
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Questions & Answers

Map of how to get from Mobile to Columbia.ExpandLaunch map view
  • Distance: 504.2 mi
  • Duration: 8h 21m

What companies run services between Mobile, AL, USA and Columbia, SC, USA?

Delta, American Airlines, and United Airlines fly from Mobile Regional Airport (MOB) to Columbia (CAE) every 4 hours. Alternatively, you can take a bus from St Joseph SB Near St Louis St to Sumter Laurel South via Govt WB Across from Greyhound, Mobile Bus Station, Atlanta, Camden, Columbia, SC, and Broad Marley South in around 15h 33m.

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